Results 101 to 110 of about 824 (151)

Effect of chain length and branching on the in vitro metabolism of a series of parabens in human liver S9, human skin S9, and human plasma.

Regulatory toxicology and pharmacology : RTP, 2021
Parabens are antimicrobial compounds used as preservatives in cosmetics, foods, and pharmaceuticals. Paraben exposure occurs through a variety of routes including dermal absorption, ingestion, and inhalation.
C. Obringer, Shengde Wu, J. Troutman, M. Karb, C. Lester   +4 more
semanticscholar   +1 more source

ω‐Phthalimidoalkyl Aryl Ureas as Potent and Selective Inhibitors of Cholesterol Esterase

ChemMedChem, 2018
Cholesterol esterase (CEase), a serine hydrolase thought to be involved in atherogenesis and thus coronary heart disease, is considered as a target for inhibitor development.
Florian M Dato, M. Sheikh, Rocky Z Uhl, Alexandra W Schüller, Michaela Steinkrüger, P. Koch, J. Neudörfl, M. Gütschow, B. Goldfuss, M. Pietsch   +9 more
semanticscholar   +1 more source

Esterase-Responsive Mitochondria-Targeted Hydropersulfide Donors Mitigate Doxorubicin Cardiotoxicity While Preserving Anticancer Activity.

Angewandte Chemie
Therapeutic agents that protect the heart from doxorubicin (DOX) toxicity without reducing its anticancer efficacy remain a critical unmet need. We report esterase-activated hydropersulfide (RSSH) donors, alkyl sulfenyl thiocarbonate (AST-2), and acetoxy
Jin-Lou Gu, Qi Liu, D. Rodríguez, J. Lamar, Klaire R Bradley, Gizem Keceli, Andrew Thampoe, Yihang Xiao, N. Paolocci, Vinayak S Khodade, John P Toscano   +10 more
semanticscholar   +1 more source

Increased levels of platelet-activating factor (1-O-alkyl-2-acetylglycerophosphocholine) in blood after reversal of renal clip hypertension in the rat.

Clinical science, 1988
H. McGowan, R. Vandongen, L. Kelly, K. J. Hill   +3 more
semanticscholar   +1 more source

Lipoprotein-associated phospholipase A2：an independent predictor of vascular risk and a novel target for therapy

, 2010
Guo-qing Zhou, Yong-jun Cao
semanticscholar   +1 more source

Detection of plasma PAF-AH and G994T single nucleotide polymorphism research in type 1 diabetes

, 2010
Yuan-yuan Zhang, G. Gao
semanticscholar   +1 more source

Possible influence of lysophospholipase on the production of 1-acyl-2-acetylglycerophosphocholine in macrophages.

Biochimica et Biophysica Acta, 1992
Yasuhito Nakagawa, Masaki Sugai, K. Karasawa, Akira Tokumura, H. Tsukatani, M. Setaka, Shoshichi Nojima   +6 more
semanticscholar   +1 more source

Expression, characterization and structural modelling of a feruloyl esterase from the thermophilic fungus Myceliophthora thermophila

Applied Microbiology and Biotechnology, 2012
E. Topakas, Maria Moukouli, M. Dimarogona, P. Christakopoulos   +3 more
semanticscholar   +2 more sources

Detection of plasma PAF-AH and gene SNP research in type 1 diabetes

, 2009
Xiao Yu
semanticscholar   +1 more source

Structure-reactivity relationships for the inhibition mechanism at the second alkyl-chain-binding site of cholesterol esterase and lipase.

Biochemistry, 1999
G. Lin, C. Shieh, H. Ho, J. Chouhwang, W. Y. Lin, C. Lu   +5 more
semanticscholar   +1 more source