Results 11 to 20 of about 824 (151)
Transcriptome-proteome compendium of the Antarctic krill (Euphausia superba): Metabolic potential and repertoire of hydrolytic enzymes [PDF]
PROTEOMICS, Volume 22, Issue 18, September 2022., 2022 The Antarctic krill (Euphausia superba Dana) is a keystone species in the Southern Ocean that uses an arsenal of hydrolases for biomacromolecule decomposition to effectively digest its omnivorous diet.Dörries, Marvin, Meyer, Bettina, Möller, Lars, Rabus, Ralf, Sohn, Kai, Vainstein, Yeheven, Wöhlbrand, Lars +6 morecore +3 more sourcesProfiling Serine Hydrolases in the Leishmania Host-Pathogen Interactome Using Cell-Permeable Activity-Based Fluorophosphonate Probes. [PDF]
ChembiochemLeishmaniasis, a vector borne neglected tropical disease, caused by the protozoan parasite Leishmania, is a major global public health challenge with millions of new cases annually.Isern JA, Porta EOJ, Kalesh K, Koutsogiannis Z, Cazzola D, Pohl E, Denny PW, Steel PG. +7 moreeuropepmc +6 more sourcesIlluminating a biologics development challenge: systematic characterization of CHO cell-derived hydrolases identified in monoclonal antibody formulations. [PDF]
MAbsMaier M, Weiß L, Zeh N, Schmieder-Todtenhaupt V, Dehghani A, Felix MN, Heinzelmann D, Lindner B, Schmidt M, Studts J, Schulz P, Reisinger B, Otte K, Franzreb M, Lakatos D, Fischer S. +15 moreeuropepmc +3 more sourcesIntegromic analysis of genetic variation and gene expression identifies networks for cardiovascular disease phenotypes [PDF]
, 2015 BACKGROUND - : Cardiovascular disease (CVD) reflects a highly coordinated complex of traits. Although genome-wide association studies have reported numerous single nucleotide polymorphisms (SNPs) to be associated with CVD, the role of most of these ...Chen, B.H., Courchesne P., Cupples L.A., Fox, C.S., Freedman J.E., Huan, T., Joehanes, R., Keles, S., Levy, D., Liu, C., Meigs J.B., Munson P.J., O'Donnell, C.J., Otlu, B., Tastan O., Yao, C., Zhang X. +16 morecore +1 more sourceDevelopment and Validation of Single Nucleotide Polymorphisms (SNPs) Markers from Two Transcriptome 454-Runs of Turbot (Scophthalmus maximus) Using High-Throughput Genotyping [PDF]
, 2013 The turbot (Scophthalmus maximus) is a commercially valuable flatfish and one of the most promising aquaculture species in Europe. Two transcriptome 454-pyrosequencing runs were used in order to detect Single Nucleotide Polymorphisms (SNPs) in genes ...Bouza Fernández, María Carmen, Fernández López, Carlos, Martínez Portela, Paulino, Vera Rodríguez, Manuel, Vilas Peleteiro, Román, Álvarez Dios, José Antonio +5 morecore +1 more sourceQuantitative comparison of catalytic mechanisms and overall reactions in convergently evolved enzymes : implications for classification of enzyme function [PDF]
, 2010 The authors thank the National Institutes of Health (NIH R01 GM60595 to PCB) and the Scottish Universities Life Sciences Alliance (SULSA to JBOM) for funding.Functionally analogous enzymes are those that catalyze similar reactions on similar substrates ...Daniel E. Almonacid, Emmanuel R. Yera, John B. O. Mitchell, Patricia C. Babbitt, Christine A. Orengo, RA George, JA Gerlt, PC Babbitt, JA Gerlt, ME Glasner, GJ Bartlett, MY Galperin, H Hegyi, ACR Martin, PF Gherardini, AE Todd, AE Todd, Z Zhang, S Tsoka, SA Teichmann, TD Otto, NH Horowitz, RA Jensen, GA Petsko, RA Chiang, CS Wright, BW Matthews, SC Morris, N Nagano, CT Porter, C Andreini, C Andreini, GL Holliday, GL Holliday, SC-H Pegg, SC-H Pegg, N Nagano, AG Murzin, G Ausiello, H Berman, NM O'Boyle, P Jaccard, P Willett, TF Smith, CA Orengo, AG McDonald, ACR Martin, SB Needleman, M Kotera, Y Yamanishi, GL Holliday, L Maveyraud, J Pitarch, R Castillo, JC Hermann, Z Wang, AP Leech, DG Gourley, AW Roszak, LM Blomberg, A Matte, MM Benning, PC Babbitt, DL Scott, BW Segelke, YS Ho, YS Ho, ME Lowe, Y Bourne, RJ Kazlauskas, H van Tilbeurgh, GJ Bartlett, T Nakai, A Zajc, E Ortlund, AB Hickman, TJ Wyckoff, CR Sweet, W Plaga, V Leppänen, F Himo, M Mathieu, Y Modis, RF Doolittle, V Sangar, BE Shakhnovich, PW Lord, J Gasteiger, O Sacher, DARS Latino, DARS Latino, DARS Latino, Y Loewenstein, T Dandekar, R Overbeek, AJ Enright, EM Marcotte, M Pellegrini, JC Hermann, JC Hermann, ME Glasner, L Jiang, M Bashton, K Tipton, KA Olszewski, R Preißner, J Park, PR Mittl, S Lorenzen, A Fersht, M Errami, EO Cannon, M Rizzi, J Symersky, Y Devedjiev, AR Battersby, N Frankenberg, MA Mathews, HL Schubert, B Stec, L Ma, JE Murphy, EB Fauman, RH Hoff, F Wang +124 morecore +3 more sourcesTranscriptome Analysis in Tardigrade Species Reveals Specific Molecular Pathways for Stress Adaptations [PDF]
, 2012 Tardigrades have unique stress-adaptations that allow them to survive extremes of cold, heat, radiation and vacuum. To study this, encoded protein clusters and pathways from an ongoing transcriptome study on the tardigrade Milnesium tardigradum were ...Beisser, Daniela, Dandekar, Thomas, Engelmann, Julia C., Frohme, Marcus, Förster, Frank, Grohme, Markus A., Liang, Chunguang, Mali, Brahim, Müller, Tobias, Schill, Ralph O., Schnölzer, Martina, Schokraie, Elham, Shkumatov, Alexander V., Siegl, Alexander Matthias +13 morecore +4 more sourcesLipoprotein‐Associated Phospholipase A2 Activity and Mass as Independent Risk Factor of Stroke: A Meta‐Analysis
BioMed Research International, Volume 2019, Issue 1, 2019., 2019 Background. The association between lipoprotein‐associated phospholipase A2 (Lp‐PLA2) and stroke risk is inconsistent. We conducted a meta‐analysis to determine whether elevated Lp‐PLA2 is a risk factor for stroke. Methods. Studies were included if they reported Lp‐PLA2 mass and/or activity levels and adjusted risk estimates of stroke.Gaifeng Hu, Deping Liu, Huiyu Tong, Weijun Huang, Yunzhao Hu, Yuli Huang, Vida Demarin +6 morewiley +1 more sourceMeta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci [PDF]
, 2016 Rationale: Abdominal aortic aneurysm (AAA) is a complex disease with both genetic and environmental risk factors. Together, 6 previously identified risk loci only explain a small proportion of the heritability of AAA.Abbate, R, Baas, AF, Badger, SA, Bailey, MA, Betsholtz, C, Bjorkegren, JLM, Blair, R, Blankensteijn, JD, Borthwick, KM, Bottinger, EP, Bown, MJ, Bradley, DT, Bridge, K, Bumpstead, S, Carey, DJ, Carrell, DS, Clough, RE, Cockerill, G, Consortium, C, Courtois, A, Crawford, DC, Crosslin, DR, de Andrade, M, de Bakker, PIW, de Graaf, J, de Vries, J-P, Deloukas, P, Drolet, AM, Eicher, JD, Elmore, JR, Erdman, R, Eriksson, P, Ferrell, RE, Folkersen, L, Franco-Cereceda, A, Franklin, DP, Franzen, O, Futers, TS, Galora, S, Geelkerken, RH, Gerhard, GS, Giusti, B, Golledge, J, Goodall, AH, Gottesman, O, Gretarsdottir, S, Griffin, KJ, Hafez, H, Hamby, SE, Harrison, SC, Hill, AA, Hill, GB, Hughes, A, Humphries, SE, Johnson, AD, Jones, GT, Kiemeney, LA, Krysa, J, Kuivaniemi, H, Kullo, IJ, Lewis, DR, Lindholt, JS, Lipovich, L, Malinowski, J, Matthiasson, SE, McCarty, CA, Merriman, TR, Nelson, CP, Norman, PE, Oszkinis, G, Pacheco, JA, Peissig, PL, Pendergrass, S, Phillips, VL, Powell, JT, Pratesi, C, Pressure, ICB, Pulli, R, Rasmussen-Torvik, LJ, Ritchie, MD, Roake, J, Romaine, SPR, Ruusalepp, A, Ryer, EJ, Sakalihasan, N, Samani, NJ, Saracini, C, Saratzis, A, Sayers, RD, Schadt, EE, Scott, DJA, Smelser, DT, Smith, A, Stefansson, K, Stirrups, K, Strauss, E, Teijink, JAW, Thompson, JR, Thompson, MM, Thomson, IA, Thorleifsson, G, Thorsteinsdottir, U, Tromp, G, van Bockxmeer, FM, van Rij, AM, van Sambeek, MR, van Sterkenburg, SM, van't Hof, FNG, Vasudevan, TM, Verhoeven, EL, Verissimo, AR, Verma, A, Verma, SS, Webb, TR, Wei, W, Wijmenga, C, Williams, MJA, Zeebregts, CJ, Zy, ZY +118 morecore +11 more sourcesTschimganine has different targets for chronological lifespan extension and growth inhibition in fission yeast [PDF]
, 2022 Tschimganine inhibits growth and extends the chronological lifespan in Schizosaccharomyces pombe. We synthesized a Tschimganine analog, Mochimganine, which extends the lifespan similar to Tschimganine but exhibits a significantly weaker growth inhibition Aiba, Hirofumi, Matsumoto, Takuma, Mochida, Takahiro, Ohtsuka, Hokuto, Shibuya, Masatoshi, Shimasaki, Takafumi, Yamamoto, Yoshihiko +6 morecore +1 more source
