Results 11 to 20 of about 678 (107)

Illuminating a biologics development challenge: systematic characterization of CHO cell-derived hydrolases identified in monoclonal antibody formulations. [PDF]

MAbs
Maier M, Weiß L, Zeh N, Schmieder-Todtenhaupt V, Dehghani A, Felix MN, Heinzelmann D, Lindner B, Schmidt M, Studts J, Schulz P, Reisinger B, Otte K, Franzreb M, Lakatos D, Fischer S.   +15 more
europepmc   +3 more sources

Integromic analysis of genetic variation and gene expression identifies networks for cardiovascular disease phenotypes [PDF]

, 2015
BACKGROUND - : Cardiovascular disease (CVD) reflects a highly coordinated complex of traits. Although genome-wide association studies have reported numerous single nucleotide polymorphisms (SNPs) to be associated with CVD, the role of most of these ...
Chen, B.H., Courchesne P., Cupples L.A., Fox, C.S., Freedman J.E., Huan, T., Joehanes, R., Keles, S., Levy, D., Liu, C., Meigs J.B., Munson P.J., O'Donnell, C.J., Otlu, B., Tastan O., Yao, C., Zhang X.   +16 more
core   +1 more source

Development and Validation of Single Nucleotide Polymorphisms (SNPs) Markers from Two Transcriptome 454-Runs of Turbot (Scophthalmus maximus) Using High-Throughput Genotyping [PDF]

, 2013
The turbot (Scophthalmus maximus) is a commercially valuable flatfish and one of the most promising aquaculture species in Europe. Two transcriptome 454-pyrosequencing runs were used in order to detect Single Nucleotide Polymorphisms (SNPs) in genes ...
Bouza Fernández, María Carmen, Fernández López, Carlos, Martínez Portela, Paulino, Vera Rodríguez, Manuel, Vilas Peleteiro, Román, Álvarez Dios, José Antonio   +5 more
core   +1 more source

Quantitative comparison of catalytic mechanisms and overall reactions in convergently evolved enzymes : implications for classification of enzyme function [PDF]

, 2010
The authors thank the National Institutes of Health (NIH R01 GM60595 to PCB) and the Scottish Universities Life Sciences Alliance (SULSA to JBOM) for funding.Functionally analogous enzymes are those that catalyze similar reactions on similar substrates ...
Daniel E. Almonacid, Emmanuel R. Yera, John B. O. Mitchell, Patricia C. Babbitt, Christine A. Orengo, RA George, JA Gerlt, PC Babbitt, JA Gerlt, ME Glasner, GJ Bartlett, MY Galperin, H Hegyi, ACR Martin, PF Gherardini, AE Todd, AE Todd, Z Zhang, S Tsoka, SA Teichmann, TD Otto, NH Horowitz, RA Jensen, GA Petsko, RA Chiang, CS Wright, BW Matthews, SC Morris, N Nagano, CT Porter, C Andreini, C Andreini, GL Holliday, GL Holliday, SC-H Pegg, SC-H Pegg, N Nagano, AG Murzin, G Ausiello, H Berman, NM O'Boyle, P Jaccard, P Willett, TF Smith, CA Orengo, AG McDonald, ACR Martin, SB Needleman, M Kotera, Y Yamanishi, GL Holliday, L Maveyraud, J Pitarch, R Castillo, JC Hermann, Z Wang, AP Leech, DG Gourley, AW Roszak, LM Blomberg, A Matte, MM Benning, PC Babbitt, DL Scott, BW Segelke, YS Ho, YS Ho, ME Lowe, Y Bourne, RJ Kazlauskas, H van Tilbeurgh, GJ Bartlett, T Nakai, A Zajc, E Ortlund, AB Hickman, TJ Wyckoff, CR Sweet, W Plaga, V Leppänen, F Himo, M Mathieu, Y Modis, RF Doolittle, V Sangar, BE Shakhnovich, PW Lord, J Gasteiger, O Sacher, DARS Latino, DARS Latino, DARS Latino, Y Loewenstein, T Dandekar, R Overbeek, AJ Enright, EM Marcotte, M Pellegrini, JC Hermann, JC Hermann, ME Glasner, L Jiang, M Bashton, K Tipton, KA Olszewski, R Preißner, J Park, PR Mittl, S Lorenzen, A Fersht, M Errami, EO Cannon, M Rizzi, J Symersky, Y Devedjiev, AR Battersby, N Frankenberg, MA Mathews, HL Schubert, B Stec, L Ma, JE Murphy, EB Fauman, RH Hoff, F Wang   +124 more
core   +3 more sources

Transcriptome Analysis in Tardigrade Species Reveals Specific Molecular Pathways for Stress Adaptations [PDF]

, 2012
Tardigrades have unique stress-adaptations that allow them to survive extremes of cold, heat, radiation and vacuum. To study this, encoded protein clusters and pathways from an ongoing transcriptome study on the tardigrade Milnesium tardigradum were ...
Beisser, Daniela, Dandekar, Thomas, Engelmann, Julia C., Frohme, Marcus, Förster, Frank, Grohme, Markus A., Liang, Chunguang, Mali, Brahim, Müller, Tobias, Schill, Ralph O., Schnölzer, Martina, Schokraie, Elham, Shkumatov, Alexander V., Siegl, Alexander Matthias   +13 more
core   +4 more sources

Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci [PDF]

, 2016
Rationale: Abdominal aortic aneurysm (AAA) is a complex disease with both genetic and environmental risk factors. Together, 6 previously identified risk loci only explain a small proportion of the heritability of AAA.
Abbate, R, Baas, AF, Badger, SA, Bailey, MA, Betsholtz, C, Bjorkegren, JLM, Blair, R, Blankensteijn, JD, Borthwick, KM, Bottinger, EP, Bown, MJ, Bradley, DT, Bridge, K, Bumpstead, S, Carey, DJ, Carrell, DS, Clough, RE, Cockerill, G, Consortium, C, Courtois, A, Crawford, DC, Crosslin, DR, de Andrade, M, de Bakker, PIW, de Graaf, J, de Vries, J-P, Deloukas, P, Drolet, AM, Eicher, JD, Elmore, JR, Erdman, R, Eriksson, P, Ferrell, RE, Folkersen, L, Franco-Cereceda, A, Franklin, DP, Franzen, O, Futers, TS, Galora, S, Geelkerken, RH, Gerhard, GS, Giusti, B, Golledge, J, Goodall, AH, Gottesman, O, Gretarsdottir, S, Griffin, KJ, Hafez, H, Hamby, SE, Harrison, SC, Hill, AA, Hill, GB, Hughes, A, Humphries, SE, Johnson, AD, Jones, GT, Kiemeney, LA, Krysa, J, Kuivaniemi, H, Kullo, IJ, Lewis, DR, Lindholt, JS, Lipovich, L, Malinowski, J, Matthiasson, SE, McCarty, CA, Merriman, TR, Nelson, CP, Norman, PE, Oszkinis, G, Pacheco, JA, Peissig, PL, Pendergrass, S, Phillips, VL, Powell, JT, Pratesi, C, Pressure, ICB, Pulli, R, Rasmussen-Torvik, LJ, Ritchie, MD, Roake, J, Romaine, SPR, Ruusalepp, A, Ryer, EJ, Sakalihasan, N, Samani, NJ, Saracini, C, Saratzis, A, Sayers, RD, Schadt, EE, Scott, DJA, Smelser, DT, Smith, A, Stefansson, K, Stirrups, K, Strauss, E, Teijink, JAW, Thompson, JR, Thompson, MM, Thomson, IA, Thorleifsson, G, Thorsteinsdottir, U, Tromp, G, van Bockxmeer, FM, van Rij, AM, van Sambeek, MR, van Sterkenburg, SM, van't Hof, FNG, Vasudevan, TM, Verhoeven, EL, Verissimo, AR, Verma, A, Verma, SS, Webb, TR, Wei, W, Wijmenga, C, Williams, MJA, Zeebregts, CJ, Zy, ZY   +118 more
core   +11 more sources

Tschimganine has different targets for chronological lifespan extension and growth inhibition in fission yeast [PDF]

, 2022
Tschimganine inhibits growth and extends the chronological lifespan in Schizosaccharomyces pombe. We synthesized a Tschimganine analog, Mochimganine, which extends the lifespan similar to Tschimganine but exhibits a significantly weaker growth inhibition
Aiba, Hirofumi, Matsumoto, Takuma, Mochida, Takahiro, Ohtsuka, Hokuto, Shibuya, Masatoshi, Shimasaki, Takafumi, Yamamoto, Yoshihiko   +6 more
core   +1 more source

Combinatorial omics analysis reveals perturbed lysosomal homeostasis in collagen VII-deficient keratinocytes [PDF]

, 2018
The extracellular matrix protein collagen VII is part of the microenvironment of stratified epithelia and critical in organismal homeostasis. Mutations in the encoding gene COL7A1 lead to the skin disorder dystrophic epidermolysis bullosa (DEB), are ...
Athanasiou, Ioannis, Backofen, Rolf, Bornert, Olivier, Bruckner-Tuderman, Leena, Dengjel, Jörn, Erxleben, Anika, Grüning, Björn Andreas, Has, Cristina, Kiritsi, Dimitra, Leppert, Juna, Nyström, Alexander, Reinheckel, Thomas, Thriene, Kerstin, Weber, Ekkehard   +13 more
core   +1 more source

Gene expression profiling of adult female tissues in feeding Rhipicephalus microplus cattle ticks [PDF]

, 2013
The southern cattle tick, Rhipicephalus microplus, is an economically important pest, especially for resource-poor countries, both as a highly adaptive invasive species and prominent vector of disease.
Maritz-Olivier, Christine, Olivier, Nicholas Abraham, Richards, Sabine, Stutzer, Christian, Van Zyl, W.A. (Willem Andries)   +4 more
core   +1 more source

Lysophosphatidylcholines - Physiological Functions in Skeletal Muscle Cells [PDF]

, 2016
Lysophosphatidylcholines (LPC) gained particular attention in metabolomics studies as potential biomarkers for metabolic diseases like obesity, insulin resistance, and type 2 diabetes mellitus.
Klingler, Christian
core   +1 more source