Results 301 to 310 of about 317,690 (321)

Exploration of Liuwei Dihuang Pill on periodontitis based on network pharmacology and molecular docking. [PDF]

Medicine (Baltimore)
Luo Y, Liu C, Liu J, Wang H, Fu Y, Liu Y.   +5 more
europepmc   +1 more source

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Linkage of reduction in 1-phosphatidylinositol 4-kinase activity and inositol 1,4,5-trisphosphate concentration in human ovarian carcinoma cells treated with quercetin

Life Sciences, 1995
Quercetin inhibited 1-phosphatidylinositol (Pl) 4-kinase, EC 2.7.1.67 (Pl kinase) activity in a concentration-dependent manner (IC50 = 4 microM) in particulate extracts from human ovarian carcinoma. In OVCAR-5 cells quercetin produced growth inhibition (IC50 = 63 microM) and cytotoxicity (LC50 = 17 microM).
Edith Olah, Katherine Y. Look, Y.Albert Yeh, George Weber, R.L. Singhal, Noemi Prajda   +5 more
openaire   +4 more sources

1-Phosphatidylinositol 4-kinase

1997
Dietmar Schomburg, Dörte Stephan
openaire   +3 more sources

1-Phosphatidylinositol 4-kinase

, 2007
Ida Schomburg, Antje Chang, Dietmar Schomburg   +2 more
openaire   +2 more sources

Quercetin down-regulates signal transduction in human breast carcinoma cells.

Biochemical and Biophysical Research Communications - BBRC, 1995
Signal transduction activity was markedly elevated in cancer cells as shown by the increased activity of enzymes utilizing 1-phosphatidylinositol, PI (PI 4-kinase and PI-4-phosphate 5-kinase) for the production of the second messenger inositol 1,4,5 ...
R. L. Singhal, Y. Yeh, N. Prajda, Edith Olah, G. Sledge, George Weber   +5 more
semanticscholar   +1 more source

Lipid kinases play crucial and multiple roles in membrane trafficking and signaling.

Histology and Histopathology, 2003
Phosphotidylinositols (PIs) are known to play an essential role in membrane trafficking and signaling transduction. PIs serve multiple functions, such as recruitment of cytosolic proteins with PI phosphate (PIP) binding domains and modification of the ...
Heath Cm, Philip D. Stahl, M. Barbieri
semanticscholar   +1 more source

Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors with in Vivo Efficacy in a Humanized Mouse Model of Malaria.

Journal of Medicinal Chemistry, 2018
A novel 2,8-disubstituted-1,5-naphthyridine hit compound stemming from the open access Medicines for Malaria Venture Pathogen Box formed a basis for a hit-to-lead medicinal chemistry program.
Nishanth Kandepedu, Diego González Cabrera, Srinivas Eedubilli, Dale Taylor, Christel Brunschwig, Liezl Gibhard, Mathew Njoroge, N. Lawrence, Tanya Paquet, C. Eyermann, T. Spangenberg, G. Basarab, L. Street, K. Chibale   +13 more
semanticscholar   +1 more source

1-Phosphatidylinositol-5-phosphate 4-kinase

, 2007
openaire   +2 more sources

Potent, selective small molecule inhibitors of type III phosphatidylinositol-4-kinase α- but not β-inhibit the phosphatidylinositol signaling cascade and cancer cell proliferation.

Chemical Communications, 2014
Two series of inhibitors of type III phosphatidylinositol-4-kinase were identified by high throughput screening and optimised to derive probe compounds that independently and selectively inhibit the α- and the β-isoforms with no significant activity ...
M. Waring, D. Andrews, P. Faulder, V. Flemington, Jennifer C. McKelvie, S. Maman, M. Preston, P. Raubo, G. Robb, K. Roberts, R. Rowlinson, James M Smith, M. Swarbrick, I. Treinies, J. Winter, R. J. Wood   +15 more
semanticscholar   +1 more source

Neuronal calcium sensor‐1 facilitates neuronal exocytosis through phosphatidylinositol 4‐kinase

Journal of Neurochemistry, 2004
Qian Zheng, Joseph A. Bobich, Jolanta Vidugirienė, Susanne C McFadden, Thomas Fairwell, John Roder, Andreas Jeromin   +6 more
openalex   +2 more sources