Results 171 to 180 of about 1,529,781 (393)

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

open access: yesMolecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau   +9 more
wiley   +1 more source

The Reality and Masquerade behind Bargaining over Welfare Pie Sizing, Delivery and Slicing. [PDF]

open access: yes
The present analysis addresses the apparently critical issue of circulation of wealth in society. Three actors play the game of welfare-related taxation.
Mullat, Joseph E.
core   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

Pertumbuhan Ekonomi, Indeks Pembangunan Manusia, Utang Luar Negeri dan Kemiskinan (Kajian Teoritis di Indonesia) [PDF]

open access: yes, 2015
This study was conducted with the intention of examining the causal relationship between the following variables: Human Development Index (HDI), foreign debt, poverty, and economic growth.
Suliswanto, M. S. (Muhammad)   +1 more
core  

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Trade Openness and Poverty Reduction in South Africa

open access: yesActa Economica
The study examined the impact of trade openness on poverty rate in South Africa. The ARDL bounds testing approach was used with annual data covering the period from 1990 to 2021.
Glenda Maluleke, Nomfundo Vacu-Nqila
doaj   +1 more source

Determinants of Monetary Poverty in the European Union [PDF]

open access: yes, 2012
The main objective of the study is to analyze the most important determinants of monetary poverty (at macro-level) in the Western EU countries taking into account the effects of regional spillovers.
Zelinsky, Tomas
core  

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

open access: yesMolecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche   +8 more
wiley   +1 more source

Kerjasama Pemerintah Desa Pasar Baru Pangean dengan Camat dalam Menuntaskan Kemiskinan di Kecamatan Pangean melalui Program Keluarga Harapan (Pkh) Tahun 2016 [PDF]

open access: yes, 2017
This research entitled "Cooperation of Village Government Pasar Baru Pangean With Camat In Completing Poverty In Pangean Sub District Through Family Hope Program (PKH) Year 2016".
Saputra, T. W. (Taufik)   +1 more
core  

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner   +6 more
wiley   +1 more source

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