100–100–100: a new, ambitious treatment target to end the HIV and hepatitis C epidemics
The Lancet Public Health, 2022 Joshua A Barocas
doaj +1 more source
JAVELIN Lung 100: updated design of a phase 3 trial of avelumab vs platinum doublet chemotherapy as first-line (1L) treatment for metastatic or recurrent PD-L1+ non-small-cell lung cancer (NSCLC) [PDF]
, 2017 Martin Reck +19 more
openalex +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
First event-by-event fluctuation studies in Pb-Pb collisions at LHC energy by the ALICE experiment
, 2011 The presence of the phase transition can manifest itself by the characteristic behavior of several observables which may vary dramatically from one event to the other.
Jena, Satyajit
core +2 more sources
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Desarrollo y SociedadNota del Editor de Desarrollo y Sociedad Ignacio Sarmiento-Barbieri sobre nuestro número 100.
Ignacio Sarmiento-Barbieri
doaj +1 more source
Results of a study of bivalve molluscs of central Asia = Итоги исследования двустворчатых моллюсков Центральной Азии [PDF]
, 2002 The article is devoted to many years’ research (1972 - 2001) of bivalve mollusks of Central Asia. It is established that it is inhabited by 51 species of molluscs belonging to 16 genera, 8 families and three orders.
Іззатуллаєв, З. І.
core
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Routing design for less-than-truckload motor carriers using ant colony techniques [PDF]
, 2004 One of the most important challenges for Less-Than-Truck-Load carriers consists of determining how to consolidate flows of small shipments to minimize costs while maintaining a certain level of service.
Barcos, Lucía +3 more
core +1 more source