This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani+14 more
wiley +1 more source
Incidence, Pattern and Mortality of Traumatic Abdominal Injury, a Three-Year Study at the Largest Trauma Center in Southern Iran: A Cross-Sectional Study. [PDF]
Yadollahi M+5 more
europepmc +1 more source
Leitfaden der Kartenentwurfslehre für Studierende der Erdkunde und deren Lehrer bearbeitet von Prof. Dr. Karl Zöppritz in zweiter neubearbeiteter und erweiterter Auflage herausgegeben von Dr. Alois Blundau. Erster Theil: Die Projectionslehre. Mit 100 Figuren und zahlreichen Tabellen. Leipzig, B. G. Teubner. 1899. [PDF]
A. Lindenkohl
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B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez+17 more
wiley +1 more source
Hypoxic adipose-derived stem cell exosomes as carriers of miR-100-5p to enhance angiogenesis and suppress inflammation in diabetic foot ulcers. [PDF]
Liu H, Hao F, Chen B.
europepmc +1 more source
LOGARITHMS OF THE VALUES OF ALL VULGAR FRACTIONS, WITH NUMERATOR AND DENMOMINATOR NOT EXCEEDING 100, ARRANGED IN ORDER OF MAGNITUDE. [PDF]
SIR G B AIRY
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Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley +1 more source
Therapeutic potential of BOLD-100, a GRP78 inhibitor, enhanced by ATR inhibition in pancreatic ductal adenocarcinoma. [PDF]
Lee SI+10 more
europepmc +1 more source