Results 311 to 320 of about 29,006,367 (387)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Optimal Branch Bending Angle for Korla Fragrant Pear: A Multi-Trait Physiological Trade-Off Framework. [PDF]

Plants (Basel)
Niyaz A, Nasir M, Zhang S, Wang S, Min C, Fan G, Muhtar D, Ma X, Tunyaz M, Yao L, Wang R, He T, Song J, Eziz M.   +13 more
europepmc   +1 more source

100 Emergencias neuroquirúrgicas

Iatreia, 2004
Ofelia Villegas Muñoz
doaj  

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Advancing prion diagnostics: full-length human E200K RT-QuIC substrate facilitates prion detection in tear fluid and improves sensitivity in cerebrospinal fluid. [PDF]

Acta Neuropathol Commun
Correia SDS, Schmitz M, Hermann P, Goebel S, Gerecke J, Lingor P, Maass F, Fischer AL, Canaslan S, Eraña H, Castilla J, Da Silva Correia A, Zerr I.   +12 more
europepmc   +1 more source

Tallinna Tehnikaülikool 100

Eesti Majanduspoliitilised Väitlused, 2018
Sulev Mäeltsemees
doaj  

Treatments for actinic prurigo: A case report with upadacitinib and systematic review. [PDF]

SAGE Open Med Case Rep
Perlmutter JW, Levy R, Sibbald C.
europepmc   +1 more source

100 Books for 100 Years

Papers of The Bibliographical Society of Canada, 2002
openaire   +2 more sources

Cefepime/enmetazobactam for Gram-negative periprosthetic joint infections? A randomized porcine study on target tissue pharmacokinetics. [PDF]

J Antimicrob Chemother
Nielsen MBD, Mikkelsen MKD, Rasmussen HC, Hvistendahl MA, Lützhøft CH, Slater J, Crocoll C, Poborsky M, Jørgensen NP, Soriano A, Stilling M, Bue M.   +11 more
europepmc   +1 more source