Results 31 to 40 of about 6,778,204 (293)

Toxicity, analgesic and sedative potential of crude extract of soil-borne phytopathogenic fungi Aspergillus flavus

Advancements in Life Sciences, 2016
Background: Aspergillus flavus is one of the most abundant mold present around the world. The present study was conducted to investigate the acute toxicity, analgesic and sedative effect of the crude extract obtained from soil borne fungi A.
Bashir Ahmad, Muhammad Rizwan, Sadiq Azam, Abdur Rauf, Shumaila Bashir   +4 more
doaj  

100 anos sem Durkheim. 100 anos com Durkheim

Sociologias
Resumo O centenário da morte de um autor é uma ocasião que convida à reflexão sobre o sentido e as consequências de seu legado. Neste texto, procuramos pontuar alguns elementos biográficos de Émile Durkheim (1858-1917), que ajudam a situá-lo em seu ...
Raquel Weiss, Rafael Faraco Benthien
doaj   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

V. Sezemanui – 100

Problemos, 2014
1984 m. gegužės 30–31 dienomis Vilniaus universitete vyko jubiliejinės iškilmės ir mokslinė konferencija, skirta Vosyliaus Sezemano 100-ųjų gimimo metinių sukakčiai paminėti. Perskaityta dešimt pranešimų, skirtų filosofo gyvenimo ir kūrybos apžvalgai (R.
Rita Šerpytytė
doaj   +1 more source

Small molecule splicing modifiers with systemic HTT-lowering activity

Nature Communications, 2021
Here the authors describe the discovery of a class of small molecule splicing modifiers which are orally bioavailable, cross the blood-brain barrier, and lower levels of huntingtin in a mouse model of Huntington’s disease (HD).
Anuradha Bhattacharyya, Christopher R. Trotta, Jana Narasimhan, Kari J. Wiedinger, Wencheng Li, Kerstin A. Effenberger, Matthew G. Woll, Minakshi B. Jani, Nicole Risher, Shirley Yeh, Yaofeng Cheng, Nadiya Sydorenko, Young-Choon Moon, Gary M. Karp, Marla Weetall, Amal Dakka, Vijayalakshmi Gabbeta, Nikolai A. Naryshkin, Jason D. Graci, Thomas Tripodi, Amber Southwell, Michael Hayden, Joseph M. Colacino, Stuart W. Peltz   +23 more
doaj   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Manifest ciberfeminista

Lectora: Revista de Dones i Textualitat, 2004
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100 anti-theses
doaj  

The Irruption of Cryptocurrencies Into Twitter Cashtags: A Classifying Solution

IEEE Access, 2020
There is a consensus about the good sensing characteristics of Twitter to mine and uncover knowledge in financial markets, being considered a relevant feeder for taking decisions about buying or holding stock shares and even for detecting stock ...
Ana Fernandez Vilas, Rebeca P. Diaz Redondo, Anton Lorenzo Garcia   +2 more
doaj   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source