Results 221 to 230 of about 134,957 (281)
A.A. Bekmuhamedov +5 more
openaire +1 more source
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang +11 more
wiley +1 more source
Variations in Seed and Fruit Traits of the Rare and Endangered Chinese Plant <i>Lilium tsingtauense</i> Along Environmental Gradients. [PDF]
Lu W +8 more
europepmc +1 more source
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng +8 more
wiley +1 more source
Chemical Composition and Biochemical Changes during Fruit Development on Seed Quality in Hot Chili (<i>Capsicum annuum</i> L.). [PDF]
Pola W, Photchanachai S, Sangsawad P.
europepmc +1 more source
Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production
ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du +4 more
wiley +1 more source
Pre-Harvest Agronomic Reduction in <i>Fusarium</i> Mycotoxins in Winter Barley: Effects of Agrotechnical Intensity on Grain Mycobiome, DON/ZEN and Feed-Quality Traits. [PDF]
Okorska SB +7 more
europepmc +1 more source
ABSTRACT Periodontitis, a chronic inflammatory disease initiated and sustained by plaque microorganisms and host immune response, remains an intractable oral disease and a leading cause of tooth loss worldwide. Traditional mechanical debridement and adjunctive antibiotic or antiseptic therapy often shows limited efficacy due to the complex anatomical ...
Weiyu Zhang +12 more
wiley +1 more source
Continued overexpression of <i>EPSPS</i> transgene enhances fitness in multigeneration crop-wild rice hybrids and its long-term environmental impact. [PDF]
Jiang XQ +7 more
europepmc +1 more source
The PBTN targets GRP78 and, upon X‐ray irradiation, generates ONOO− to induce immunogenic cell death, thereby activating CD8+ T cells and establishing a systemic antitumor immune response. ABSTRACT Nitric oxide (NO) treated radioresistant tumors by relieving hypoxia and blocking DNA repair, but its nonselective toxicity has precluded therapeutic use ...
Wanze Zhang +10 more
wiley +1 more source

