Results 31 to 40 of about 9,085,631 (304)
Learning to Calibrate Battery Models in Real-Time with Deep Reinforcement Learning
Energies, 2021 Lithium-ion (Li-I) batteries have recently become pervasive and are used in many physical assets. For the effective management of the batteries, reliable predictions of the end-of-discharge (EOD) and end-of-life (EOL) are essential.
Ajaykumar Unagar +3 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
MedEdPORTAL, 2007 Coding 101 is an online curriculum designed for residents. The curriculum includes three audiovisual modules and suggested supplementary online resources.
Davoren Chick
doaj +1 more source
Clinics in Colon and Rectal Surgery, 2013 Writing a grant is a hefty undertaking. Start by surrounding yourself with a successful mentor and accompanying team with a good track record. Get organized, select clear goals and objectives to your project. Once the foundation for the grant is set, begin by generating a robust hypothesis.
Jason T, Wiseman +2 more
openaire +2 more sources
, 2017 Dunlap discusses the concept of lawfare—using law as a form of asymmetrical warfare—and provides some considerations for how to combat this phenomenon. The article establishes the intellectual framework and thematic direction for this Issue of Military ...
Dunlap, Charles J., Jr.
core +1 more source
Identification of a novel polyprenylated acylphloroglucinol‑derived SIRT1 inhibitor with cancer‑specific anti-proliferative and invasion-suppressing activities [PDF]
, 2014 SIRT1, a class III histone deacetylase, plays a critical role in regulating cancer cell growth, migration and invasion, which makes it a potential target for cancer therapeutics.
Chiao, Christine Ya-Chi +6 more
core +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Biomolecules, 2022 Protein aggregation is a well-recognized problem in industrial preparation, including biotherapeutics. These low-energy states constantly compete with a native-like conformation, which is more pronounced in the case of macromolecules of low stability in ...
Marcin Mielecki +6 more
doaj +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Understanding the Doctrine of Patentable Subject Matter [PDF]
, 2010 The doctrine of patentable subject matter precludes basic inventions such as abstract ideas and laws of nature from patent protection. However, current economic thinking of the patent systemstresses the necessity of rewarding pioneering inventors in ...
Chiou, Jing-Yuan
core