Results 91 to 100 of about 1,883,513 (341)

Plasma‐activated media selectively induces apoptotic death via an orchestrated oxidative stress pathway in high‐grade serous ovarian cancer cells

Molecular Oncology, EarlyView.
High‐grade serous ovarian cancer (HGSOC) is the most common and aggressive type of ovarian cancer with urgent need for new treatment strategies. This study evaluates plasma‐activated media (PAM) as a novel treatment for HGSOC, showing its ability to selectively induce oxidative stress and apoptosis in HGSOC cell lines, patient ascites cells and primary
Lorena T. Davies, Raja Ganesen, John Toubia, Sung‐Ha Hong, Sushil Kumar KC, Martin K. Oehler, Carmela Ricciardelli, Endre J. Szili, Nirmal Robinson, Melissa R. Pitman   +9 more
wiley   +1 more source

Balancing Progress and Responsibility: A Synthesis of Sustainability Trade-Offs of AI-Based Systems [PDF]

Recent advances in artificial intelligence (AI) capabilities have increased the eagerness of companies to integrate AI into software systems. While AI can be used to have a positive impact on several dimensions of sustainability, this is often overshadowed by its potential negative influence.
arxiv   +1 more source

Bioclimatology, structure, and conservation perspectives of Quercus pyrenaica, Acer opalus subsp. Granatensis, and Corylus avellana deciduous forests on Mediterranean bioclimate in the South-Central part of the Iberian Peninsula [PDF]

, 2019
The plant variability in the southern Iberian Peninsula consists of around 3500 different taxa due to its high bioclimatic, geographic, and geological diversity.
Cano, E., Cano-Ortiz, A., Gomes, C.J. Pinto, Musarella, C. M., Piñar Fuentes, J. C., Quinto Canas, R., Río, S. del, Spampinato, G.   +7 more
core   +2 more sources

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

Molecular Oncology, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti, Shingo Inagaki, Tuyen Thuy Bich Ho, Akihiro Seki, Keiko Yoshida, Kosuke Satomura, Yoshio Sakai, Shuichi Kaneko, Taro Yamashita   +8 more
wiley   +1 more source

Water status and yield response to deficit irrigation and fertilization of three olive oil cultivars under the semi-arid conditions of Tunisia [PDF]

, 2019
Sustainability of olive production is possible by adopting the modern techniques of irrigation and fertilization. In Tunisia, olive trees are usually cultivated in poor soils, under semi-arid conditions characterized by water scarcity.
Attia F., Khebour F. A., Mezghani M. A., Mguidiche A., Provenzano G., Zouari I.   +5 more
core   +1 more source

Clinical significance of stratifying prostate cancer patients through specific circulating genes

Molecular Oncology, EarlyView.
We tested a specific panel of genes representative of luminal, neuroendocrine and stem‐like cells in the blood of prostate cancer patients, showing predictive value from diagnosis to late stages of disease. This approach allows monitoring of treatment responses and outcomes at specific time points in trajectories.
Seta Derderian, Edouard Jarry, Arynne Santos, Quentin Vesval, Lucie Hamel, Rafael Sanchez‐Salas, Alexis Rompré‐Brodeur, Wassim Kassouf, Raghu Rajan, Fadi Brimo, Marie Duclos, Armen Aprikian, Simone Chevalier   +12 more
wiley   +1 more source

Family management and firm performance in family SMEs: the mediating roles of management control systems and technological innovation [PDF]

, 2019
The aim of this research is to analyze the mediating role of the use of management control systems (MCS) and the achievement of technological innovation (TI) in the relationship between family management and firm performance in family small and medium ...
Anderson, Antonio Duréndez, Briones Peñalver, Chenhall, Chrisman, Conte, Daniel Ruiz-Palomo, Duran, Freeman, Hair, Henseler, José António C. Santos, Julio Diéguez-Soto, Kaplan, Kaplan, López-Fernández, Miller, Ortega-Argilés, Richard, Schmid, Sciascia, Simons, Souitaris, Strecker, von Krogh   +24 more
core   +3 more sources

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Wood Distillate Mitigates Ozone-Induced Visible and Photosynthetic Plant Damage: Evidence from Ozone-Sensitive Tobacco (Nicotiana tabacum L.) BelW3

Horticulturae
The use of wood distillate (WD) is emerging as a valuable strategy for protecting horticultural crops from the oxidizing effects of ozone (O3). To fully understand its effectiveness, extensive testing on different plant species is needed.
Andrea Vannini, Alessandro Petraglia
doaj   +1 more source

Genetic diversity and structure of the portuguese pear (Pyrus communis L.) germplasm [PDF]

, 2019
A rich heritage of traditional pear varieties is kept in national Portuguese collections. Out of these varieties, “Rocha” dominates national pear production.
Guimarães, Joana Bagoin, Queiroz, Álvaro, Simões, Fernanda, Sousa, Rui Maia, Sánchez, Claudia, Veloso, Maria Manuela, Viegas, Wanda   +6 more
core   +1 more source