Results 101 to 110 of about 6,727,883 (339)

Mapping the Landscape of Citizen Science in Africa: Assessing its Potential Contributions to Sustainable Development Goals 6 and 11 on Access to Clean Water and Sanitation and Sustainable Cities [PDF]

, 2023
Peter Elias, Adenike Shonowo, Alex de Sherbinin, Carolynne Hultquist, Finn Danielsen, Caren B. Cooper, M.R. Mondardini, Elaine M. Faustman, Anne Browser, J. B. Minster, Martie Van Deventer, Ioana Popescu   +11 more
openalex   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Leading corporate sustainability: The role of top management team composition for triple bottom line performance

Business Strategy and the Environment, 2018
Sustainable development at the corporate level requires balancing social, environmental, and financial performance goals. Achieving such “triple bottom line” (TBL) performance is a very challenging task.
L. Henry, Tine Buyl, Rob J G Jansen
semanticscholar   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

How Can Innovation in Urban Agriculture Contribute to Sustainability? A Characterization and Evaluation Study from Five Western European Cities

Sustainability, 2019
Compared to rural agriculture, urban agriculture (UA) has some distinct features (e.g., the limited land access, alternative growing media, unique legal environments or the non-production-related missions) that encourage the development of new practices,
E. Sanyé‐Mengual, K. Specht, E. Grapsa, F. Orsini, G. Gianquinto   +4 more
semanticscholar   +1 more source

Aspergillus flavus as a Model System to Test the Biological Activity of Botanicals: An Example on Citrullus colocynthis L. Schrad. Organic Extracts

Toxins, 2019
Citrullus colocynthis L. Schrader is an annual plant belonging to the Cucurbitaceae family, widely distributed in the desert areas of the Mediterranean basin.
Francesca Degola, Belsem Marzouk, Antonella Gori, Cecilia Brunetti, Lucia Dramis, Stefania Gelati, Annamaria Buschini, Francesco M. Restivo   +7 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The Sustainable Development Goals – SDG#11 Sustainable Cities and Communities

, 2023
Full ...
Hales, Rob, Birdthistle, Naomi
openaire   +2 more sources