Results 111 to 120 of about 1,883,513 (341)

Conceptual Design and Parametric Optimization of a New Multileveled Horsetail Structure for Bicycle Helmets

open access: yesAdvanced Engineering Materials, EarlyView., 2023
This study aims to explore the feasibility of using a structure inspired by the features of horsetail and human spine as the potential helmet liner, targeting at mitigation of acceleration‐induced injuries. A parametric study is conducted to investigate the effect of individual geometrical variables in the design, indicating its capability to reduce ...
Bing Leng   +3 more
wiley   +1 more source

Optimal Alignments for Designing Urban Transport Systems: Application to Seville [PDF]

open access: yes, 2019
The achievement of some of the Sustainable Development Goals (SDGs) from the recent 2030 Agenda for Sustainable Development has drawn the attention of many countries towards urban transport networks. Mathematical modeling constitutes an analytical tool
Marseglia, Guido   +3 more
core  

Revisiting CDKN2A dysregulation in Ewing sarcoma

open access: yesMolecular Oncology, EarlyView.
We revisit CDKN2A to investigate its role as a potential prognostic biomarker in Ewing sarcoma using data from pre‐clinical models as well as clinical samples. Ewing sarcoma (EwS) is a rare and aggressive malignancy, which frequently affects children.
Anjali Paragji   +8 more
wiley   +1 more source

A Variational Beam Model for Failure of Cellular and Truss‐Based Architected Materials

open access: yesAdvanced Engineering Materials, EarlyView., 2023
Herein, a versatile and efficient beam modeling framework is developed to predict the nonlinear response and failure of cellular, truss‐based, and woven architected materials. It enables the exploration of their design space and the optimization of their mechanical behavior in the nonlinear regime. A variational formulation of a beam model is presented
Konstantinos Karapiperis   +3 more
wiley   +1 more source

Aspergillus flavus as a Model System to Test the Biological Activity of Botanicals: An Example on Citrullus colocynthis L. Schrad. Organic Extracts

open access: yesToxins, 2019
Citrullus colocynthis L. Schrader is an annual plant belonging to the Cucurbitaceae family, widely distributed in the desert areas of the Mediterranean basin.
Francesca Degola   +7 more
doaj   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

Software Sustainability: A Systematic Literature Review and Comprehensive Analysis [PDF]

open access: yesarXiv, 2019
Software Engineering is a constantly evolving subject area that faces new challenges every day as it tries to automate newer business processes. One of the key challenges to the success of a software solution is attaining sustainability. The inability of numerous software to sustain for the desired time-length is caused by limited consideration given ...
arxiv  

Thermal Perception in Mild Climate: Adaptive Thermal Models for Schools [PDF]

open access: yes, 2019
A comprehensive assessment of indoor environmental conditions is performed on a representative sample of classrooms in schools across southern Spain (Mediterranean climate) to evaluate the thermal comfort level, thermal perception and preference, and ...
Campano Laborda, Miguel Ángel   +3 more
core  

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