Results 191 to 200 of about 17,398,133 (240)

Oscillometric blood pressure values in infants at 3, 6 and 12 months of age: a cohort study. [PDF]

BMJ Paediatr Open
Ørbeck Vallevik E, Holten-Andersen MN, Lødrup Carlsen KC, Skjerven HO, Vettukattil R, Rueegg CS, Rehbinder EM, Nordlund B, Söderhäll C, Hedlin G, Haugen GN, Staff AC, Nilsen M, Holmstrøm H.   +13 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Disease burden of untreated thymidine kinase 2 deficiency: insights from a large patient dataset. [PDF]

Brain Commun
Domínguez-González C, Garone C, Nascimento A, Ma Y, Boudiaf N, Kim R, VanMeter S, Brunnert M, Hirano M.   +8 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Ethnomedicinal plants used by Guoshan Yao minority communities in the foothills of Nanling Mountain, Guangdong, China. [PDF]

J Ethnobiol Ethnomed
Khadka D, Chen B, Xie Y, Shui K, Zhang X, Liu Z, Song L, Zhang C, Li Y, Lee TM, Liao W, Shi S, Fan Q.   +12 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Health-related quality of life experiences in children with bladder exstrophy-epispadias complex: a Swedish focus group study. [PDF]

Qual Life Res
Svenninghed U, Öst E, Holmdahl G, Örtqvist L, Boije M, Sjöström S, Blom MD.   +6 more
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Safety and effectiveness of tocilizumab in systemic sclerosis: a multicentre French-Italian study. [PDF]

RMD Open
Buonsante G, De Luca G, Marazzi E, Cacciapaglia F, Lazzaroni MG, De Pinto M, Benfaremo D, Longo V, Iandoli C, Cuomo G, Cuberli A, Zanatta E, Lescoat A, Bellando-Randone S, Trignani G, Guiducci S, Beretta L, Moroncini G, Giuggioli D, Airò P, Iannone F, Codullo V, Bosello SL, Del Papa N, Truchetet ME, Avouac J, Dagna L, Matucci-Cerinic M, Allanore Y, Campochiaro C.   +29 more
europepmc   +1 more source