Results 271 to 280 of about 46,388,210 (340)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Quantifying urban and landfill methane emissions in the United States using TROPOMI satellite data. [PDF]

Sci Adv
Wang X, Jacob DJ, Nesser H, Balasus N, Estrada LA, Sulprizio MP, Cusworth DH, Scarpelli TR, Chen Z, East JD, Varon DJ.   +10 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

From QI-disability to QID-12: creating a brief proxy-report measure of quality of life for children with intellectual disability. [PDF]

Qual Life Res
Licari MK, Whitehouse AJO, Ludwig NN, Wojnaroski M, Hommer R, Conecker G, Hecker J, Muzyczka K, Leonard H, Williams KJ, Reddihough DS, Downs J, Jacoby P.   +12 more
europepmc   +1 more source

Evelyn Chapel to Hold All Saint’s Day Service [PDF]

, 2009
Griffin ’12, Hannah
core   +2 more sources

An Immunomodulating Peptide With Potential to Counteract Endometriosis. [PDF]

Aust N Z J Obstet Gynaecol
Agrez M.
europepmc   +1 more source

Return to Sports and Clinical Outcomes After Medial Ulnar Collateral Ligament Reconstruction With Semitendinosus Allograft in Overhead Athletes: A Retrospective Case Series. [PDF]

Orthop J Sports Med
Moews LD, Saad-Berreta R, Khan ZA, Thamrongskulsiri N, Engel JO, Jones GE, Hornung AL, Brinkman JC, Verma NN, Cohen MS.   +9 more
europepmc   +1 more source

Pulsed field vs radiofrequency ablation for paroxysmal atrial fibrillation: the BEAT PAROX-AF trial. [PDF]

Eur Heart J
Jais P, Neuzil P, Scherr D, Frison E, Knecht S, Boveda S, Deisenhofer I, Maury P, Deneke T, Cochet H, Rousset M, Renaudeau V, Sauer E, Sermesant M, Kautzner J, Erhard N, Wichterle D.   +16 more
europepmc   +1 more source