Results 81 to 90 of about 17,398,133 (240)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
GENERAL-AGENTUREN A.KAHN,FRANKFURT A.M. 12 KÖNIGSWARTERSTRASSE 12 GEGRÜNDET 1894 GENERALVERTRETUNG SPECIALFABRIK FÜR GEKÄMMTE&LANGGESTRECKTE SAND&STAUBFREIE WEISSE&BUNTE PUTZWOLLE General-Agenturen A.Kahn,Frankfurt a.M.
General-Agenturen A.Kahn,Frankfurt a.M. 12 Königswarterstrasse
core +1 more source
GENERAL-AGENTUREN A.KAHN,FRANKFURT A.M. 12 KÖNIGSWARTERSTRASSE 12 GEGRÜNDET 1894 GENERALVERTRETUNG SORTIERANSTALT FÜR GROSSSTÜCKIGE GEWASCHENES DESINFIZIERTE WEISSE & BUNTE PUTZ&POLIERLAPPEN General-Agenturen A.Kahn,Frankfurt a.M. 12 Königswarterstrasse
General-Agenturen A.Kahn,Frankfurt a.M. 12 Königswarterstrasse
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Table of Content- Vol 12, No 2 (2018)
, 2018 Table of Content- Vol 12, No 2 ...
No 2 (2018), Vol 12,
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
, 2015 วารสารการอาชีวะและเทคนิคศึกษา ปีที่ 6 ฉบับที่ 12 กรกฎาคม-ธันวาคม พ.ศ ...
สารบัญ ฉบับที่11, หน้าปกใน ฉบับที่11 +2 more
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Journal of NeuroinflammationThe inflammatory processes that drive pathologies of the central nervous system (CNS) are complex and involve significant contributions from the immune system, particularly myeloid cells.
Blanca Cómitre-Mariano +5 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
GENERAL-AGENTUREN A.KAHN,FRANKFURT A.M. 12 KÖNIGSWARTERSTRASSE 12 GEGRÜNDET 1894 GENERALVERTRETUNG SPECIALFABRIK FÜR FEUERSICHERE PUTZWOLLKASTEN,TROPFÖL-REINIGER & UNIVERSAL-ÖLSPAR&ABFÜLL-APPARATE General-Agenturen A.Kahn,Frankfurt a.M.
General-Agenturen A.Kahn,Frankfurt a.M. 12 Königswarterstrasse
core +2 more sources