Results 71 to 80 of about 1,315,727 (319)

Frailty Exacerbates Disability in Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks, Anna Wolska, Diala Ghazal, Dejan Jakimovski, Bianca Weinstock‐Guttman, Alexander Burnham, Niels Bergsland, Michael G. Dwyer, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +10 more
wiley   +1 more source

Delivering sustainable climate action: reframing the sustainable development goals

npj Climate Action
Globally, climate change represents the most significant threat to the environment and socio-economic development, endangering lives and livelihoods. Within the UN’s current 17 Sustainable Development Goals (SDGs), climate action is explicitly covered ...
Ajit Singh, Francis D. Pope, Jonathan Radcliffe, Carlo Luiu, Hakeem Bakare, Suzanne E. Bartington, Nana O. Bonsu, John R. Bryson, Nic Cheeseman, Heather Flowe, Stefan Krause, Karen Newbigging, Fiona Nunan, Louise Reardon, Christopher D. F. Rogers, Karen Rowlingson, Ian Thomson   +16 more
doaj   +1 more source

Glymphatic Dysfunction Reflects Post‐Concussion Symptoms: Changes Within 1 Month and After 3 Months

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mild traumatic brain injury (mTBI) may alter glymphatic function; however, its progression and variability remain obscure. This study examined glymphatic function following mTBI within 1 month and after 3 months post‐injury to determine whether variations in glymphatic function are associated with post‐traumatic symptom severity ...
Eunkyung Kim, Han Gil Seo, Roh‐Eul Yoo, Byung‐Mo Oh   +3 more
wiley   +1 more source

Effectiveness and Safety of Nusinersen and Risdiplam in Spinal Muscular Atrophy: A Systematic Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinal Muscular Atrophy (SMA) is a rare genetic disorder marked by progressive muscle weakness and mobility loss. It has a profound physical, emotional and social impact on patients and caregivers, requiring comprehensive medical and supportive care.
Amin Mehrabian, Peter Auguste, Amy Grove, Anna Brown, Janette Parr, Mubarak Patel, Furqan Butt, Jeremiah Donoghue, Mehdi Yousefi, Jo Parsons   +9 more
wiley   +1 more source

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall   +5 more
wiley   +1 more source

Climate Policy in the United States and Japan: A Workshop Summary [PDF]

Resources for the Future and the Institute for Global Environmental Strategies (Japan) convened a one-and-one-half day workshop on domestic and international climate policy on February 12–13, 2004 in Washington, D.C.
Pizer, William, Tamura, Kentaro
core  

Variably Protease‐Sensitive Prionopathy: Two New Cases With Motor Neuron‐Dementia Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We describe two patients with variably protease‐sensitive prionopathy (VPSPr) who developed progressive upper motor neuron symptoms, insomnia, behavioral and cognitive decline, compatible with primary lateral sclerosis associated with frontotemporal dementia (FTD).
María Elena Erro, María Victoria Zelaya, Hasier Eraña, Javier Sánchez Ruiz de Gordoa, Fermín García‐Amigot, Anika Simonovska‐Serra, María Cristina Caballero, Isidre Ferrer, Ellen Gelpi, Ivonne Jericó, Joaquín Castilla   +10 more
wiley   +1 more source

Staying on Track from Paris: Advancing the Key Elements of the Paris Agreement [PDF]

, 2016
The Paris Agreement adopted in December 2015 provides essential building blocks for universal action to address climate change. Now, much work is needed to breathe life into the provisions and commitments of the Agreement in order to realize the globally
Cynthia Elliott, David Waskow, Eliza Northrop, Heather McGray, Joe Thwaites, Kathleen Mogelgaard, Kelly Levin, Melisa Krnjaic, Yamide Dagnet   +8 more
core  

Neuropsychiatric Symptoms Mimicking Dementia in a Patient Treated With Imatinib

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Tyrosine kinase inhibitors are the cornerstone of chronic myeloid leukemia treatment. Newer agents have more potency and a broader spectrum of action, but also a higher potential for neuropsychiatric side effects. We present a case of a patient on imatinib who developed progressive cognitive, mood, and behavioral alterations.
Ashley Jones, Samuele Bonomi, Keith E. Stockerl‐Goldstein, Randall J. Bateman   +3 more
wiley   +1 more source

Climate action and resilience strategies for achieving SDG 13 in the North Western Himalayas

Discover Environment
Due to the natural phenomenon of climate change and its increasing rate because of human-induced pressure, the North-western Himalayan Mountain region, which is also an ecologically and tectonically active landscape, is becoming increasingly vulnerable ...
Suhail Ahmad Dar, Priyanka Verma, Mohd Younis Mir, Sumalya Ray, Hakima Banoo, Sajad Nabi Dar   +5 more
doaj   +1 more source