Results 101 to 110 of about 12,390 (186)

Synergistic p53 Pathway Activation Through Sono‐Gene Therapy Induced by Ultrasound‐Triggered Theranostic Mesoporous Nanoparticles

open access: yesAdvanced Science, EarlyView.
Schematic representation of ultrasound‐mediated ICG/siCD24@MSN‐LCD from nanostructure to synergistic sono‐gene therapy. This nanoplatform targets ASGPR via the LCD shell, which dissociates to release loaded ICG and siCD24. The core mechanism involves ultrasound‐guided sonodynamic therapy by ICG and CD24 knockdown by siCD24, both activating the p53 axis
Yading Zhao   +11 more
wiley   +1 more source

Lanthanum Carbonate Nanosheets Based Colloidal Hydrogel for Modulating Innate & Adaptive Tumor Immunotherapy by Augmented Cellular Pyroptosis

open access: yesAdvanced Science, EarlyView.
The Gela/decitabine/La2(CO3)3 colloidal (GDLC) hydrogel developed here could reverse the epigenetic silencing of the GSDME gene by the synergistic interaction between DAC and La3+, while concurrently activating caspase‐3, thus facilitating pyroptosis induction under the tumor microenvironment.
Yang Hong   +6 more
wiley   +1 more source

Intranasal Delivery of Gallium–Quercetin Nanoparticles for Multi‐Target Ferroptosis Inhibition in Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
Leveraging the chemical similarity between Ga3+ and Fe3+ as well as the antioxidant properties of quercetin, gallium–quercetin nanoparticles (GQNPs) were prepared to integrate iron homeostasis regulation, oxidative stress suppression, and mitochondrial protection for multi‐target ferroptosis inhibition in Parkinson's Disease.
Keyang Xu   +12 more
wiley   +1 more source

Multimodal Bioinspired Self‐Healing Composites Enabling Durable and High‐Efficiency Wearable Perovskite Light‐Emitting Diodes

open access: yesAdvanced Science, EarlyView.
Butterfly wing–inspired intrinsically self‐healing polymer interlayers enable flexible perovskite optoelectronics with high luminance, strain‐insensitive stability, and environmental resilience. These hierarchically structured films redistribute mechanical stress, suppress defect formation, and maintain performance under repeated bending, paving the ...
Loganathan Veeramuthu   +13 more
wiley   +1 more source

Randomized preclinical study of machine perfusion in vascularized composite allografts

open access: yesBJS (British Journal of Surgery), EarlyView., 2020
This study was designed to identify the optimum machine perfusion parameters for preservation of limbs before transplantation, and determine whether this was better than cold storage. Normothermic machine perfusion at a pressure of 70 mmHg (NMP‐70) provided superior preservation to cold storage after transplantation.
K. R. Amin   +7 more
wiley   +1 more source

Wine Bottle Refinement: A Review of Emerging Aging Strategies. [PDF]

open access: yesFoods
Mercanti N   +6 more
europepmc   +1 more source

Structured sorbents for Direct Air Capture: The impact of materials and chemicals on performance

open access: yesAIChE Journal, EarlyView.
Abstract Structured sorbents can efficiently process large air volumes required for Direct Air Capture (DAC), but their broad implementation is limited by challenges in producing reproducible and homogeneous materials. This work presents a robust procedure to graft amines onto monolithic sorbents and systematically investigates how CO2$$ {\mathrm{CO ...
Nicole Ferru   +8 more
wiley   +1 more source

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