Results 211 to 220 of about 6,710,335 (243)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Systemic Drivers and Molecular Mechanisms of Sarcopenia in Aetiology-Specific End-Stage Liver Disease. [PDF]

J Cachexia Sarcopenia Muscle
Nicholson T, Allen SL, Quinlan JI, Dhaliwal A, Macleod M, Price J, Hazeldine J, Sagmeister MS, Ditchfield C, McGee KC, Williams FR, Elsharkawy AM, Armstrong MJ, Greig CA, Lord JM, Breen L, Jones SW.   +16 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Mol-ecular and crystal structure of <i>catena</i>-poly[1-benzyl-[1,2,4]triazolo[1,5-<i>c</i>]quinazolin-1-ium-2,5-bis-(thiol-ate) [[aqua-sodium]-di-μ-aqua]]. [PDF]

Acta Crystallogr E Crystallogr Commun
Shishkina SV, Kovalenko MS, Drushlyak OG, Shyshkina MO, Dank C, Kovalenko SM.   +5 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Remote Changes of Mechanical Stiffness Following Local Stretching or Contraction: A Systematic Review with Meta-Analysis. [PDF]

Sports Med Open
Kretschmer L, Wilke J.
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Sheath-Liquid CE-MS Interface: A Robust Infusion Platform for Native IMS-MS Analysis of Protein Assemblies and Their Conformers. [PDF]

J Mass Spectrom
Pathak K, Brinkman D, Gomes FP.
europepmc   +1 more source

Sesquiterpenoids from <i>Dysoxylum acutangulum</i> Miq. and <i>Dysoxylum cauliflorum</i> Hiern Twigs: Antibiofilm Activity Against <i>Streptococcus mutans</i>. [PDF]

Molecules
Anwar R, Ainazzahra H, Inayah CNU, Naini AA, Juliansyah E, Permadi EE, Nugroho A, Farabi K, Supratman U.   +8 more
europepmc   +1 more source

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Spanish Democracy and 15-M

2020
Abstract Chapter 1, “Spanish Democracy and 15-M,” explores the political opportunities provided by the historical, cultural, and economic context in which the movement emerged. It argues that translating economic grievances into sustained mobilization and protest requires the concerted effort of collective actors, as the variance in ...
openaire   +1 more source