Results 121 to 130 of about 7,838 (225)

Integrative in silico and in vitro screening of small molecules targeting RNA

Current Protocols, Volume 6, Issue 8, August 2026.
Abstract Targeting structured RNA elements with small molecules has emerged as a promising yet technically challenging strategy for antiviral drug discovery. Here, we present a comprehensive and experimentally validated workflow for the integrative in silico and in vitro screening of RNA‐binding small molecules.
Sabrina Toews, Megan Ken, Harald Schwalbe   +2 more
wiley   +1 more source

Energy Channel Coupling by Mid‐Trophic Level Fish Challenges the Landscape Theory for Food Web Architecture in a Large Tropical Lake Ecosystem

Ecology and Evolution, Volume 16, Issue 8, August 2026.
Lake Turkana, a large tropical East African Great Lake, is an ideal model for examining how consumer fish species may mediate the coupling of fast and slow energy channels within food webs. We explored the ecological niche dynamics of five important Lake Turkana fish species across ontogeny and used a Bayesian isotope mixing model approach to identify ...
Madison F. Muehl, Jill A. Olin, James L. Keyombe, Josephine Y. Aller, Robert M. Cerrato   +4 more
wiley   +1 more source

A Triple-Resonance NMR Strategy for the Selective Detection of NAD⁺ and NADH Derived from a ¹³C/¹⁵N-Nicotinamide Riboside Probe in the Liver Extracts of Mice. [PDF]

Sensors (Basel)
Shimada H, Shinohara Y, Uto Y, Yamada H.
europepmc   +1 more source

Managing the Environmental Impacts of Outdoor Winter Grazing by Livestock

New Zealand Journal of Agricultural Research, Volume 69, Issue 4, August 2026.
This review presents a synthesis of current knowledge about managing the potential impacts of outdoor animal wintering activities and their consequences for a range of environmental outcomes. The scope is confined to field‐based wintering approaches and thus, does not consider issues associated with the winter use of animal shelters or standoff systems.
Ross M. Monaghan, Brendon Malcolm, Chandra Ghimire, L. Chris Smith, Bob Longhurst   +4 more
wiley   +1 more source

Hydrazinoacetic acid is a biosynthetic precursor of the bacterially produced nitramine, <i>N</i>-nitroglycine. [PDF]

Appl Environ Microbiol
Padilla G, Rathman BM, Vaddypally S, Martinez Rodriguez B, Zdilla MJ, Graham DE, Caranto JD.   +6 more
europepmc   +1 more source

Understanding Mass Spectrometry: From Ion Generation to Spectral Interpretation

Journal of Mass Spectrometry, Volume 61, Issue 8, August 2026.
ABSTRACT This tutorial provides a structured introduction to mass spectrometry (MS), with particular emphasis on electrospray ionization (ESI)–based measurements. It is intended to support researchers from chemistry and related disciplines in developing a coherent understanding of MS principles, instrumentation, and data interpretation.
Arnold Steckel, Dávid Papp, Gitta Schlosser   +2 more
wiley   +1 more source

Nitrate Availability Modulates the Temperature Sensitivity of N₂O and N₂ Production From Denitrification. [PDF]

Glob Chang Biol
Si Y, Trimmer M.
europepmc   +1 more source

Metabolic Assessment in Human Pluripotent Stem Cell‐Derived Cerebral Organoids Using HR‐MAS NMR Spectroscopy

NMR in Biomedicine, Volume 39, Issue 8, August 2026.
We present a direct method for evaluating metabolism in intact hPSC‐derived cerebral organoids (COs) via HR‐MAS 1H‐NMR spectroscopy. This approach suggests that COs exhibit a metabolic profile similar to in vivo human fetal brain, with high levels of lactate and hTau, low levels of NAA, and equimolar levels of Glu and Gln.
Maria Alejandra Castilla Bolanos, Vorapin Chinchalongporn, Rajshree Ghosh Biswas, Colleen Bailey, Maggie Wu, Ronald Soong, Fermisk Saleh, Andre Simpson, Carol Schuurmans, Jamie Near   +9 more
wiley   +1 more source

Nitrogen Assimilation in the Freshwater Amphipod <i>Gammarus fossarum</i> is Dominated by Animal-Derived Resources. [PDF]

Ecol Evol
Amann K, Hoess R, Auerswald K, Geist J.
europepmc   +1 more source

Damping amyloid‐associated conformational fluctuations in a protein by an engineered diselenide bridge

Protein Science, Volume 35, Issue 8, August 2026.
Abstract Polypeptide cross‐β assembly, characteristic of diverse proteotoxic diseases, defines a general thermodynamic ground state and limits the shelf lives of peptide‐ and protein therapeutics. A model is provided by insulin. Although the hormone contains a predominance of α‐helix, its fibrils exhibit cross‐β reorganization.
Yanwu Yang, Balamurugan Dhayalan, Andreas Ehnbom, Orit Weil‐Ktorza, Norman Metanis, Michael A. Weiss   +5 more
wiley   +1 more source