Results 341 to 350 of about 712,979 (385)

The influence of ROS1 fusion partners and resistance mechanisms in ROS1‐TKI‐treated non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
This real‐world study of ROS1+ NSCLC highlights fusion diversity, treatment outcomes with crizotinib and lorlatinib, and in vitro experiments with resistance mechanisms. G2032R drives strong resistance to ROS1‐targeted TKIs, especially lorlatinib. Fusion partner location does not affect overall survival to crizotinib or lorlatinib. Findings support the
Fenneke Zwierenga, Christa Dijkhuizen, Patrick Korthuis, Wim Timens, Harry Groen, Jeroen Hiltermann, Anke van den Berg, Lyndsay Drayer, Anthonie van der Wekken   +8 more
wiley   +1 more source

Anchorage accurately assembles anchor-flanked synthetic long reads. [PDF]

Algorithms Mol Biol
Zang XC, Li X, Metcalfe K, Ben-Yehezkel T, Kelley R, Shao M.   +5 more
europepmc   +1 more source

16. Februar 1916

, 2016
openaire   +8 more sources

Hypomethylating agents increase L1 retroelement expression without inducing novel insertions in myeloid malignancies

Molecular Oncology, EarlyView.
We investigated whether hypomethylating agents (HMAs) used in myeloid malignancies induce somatic retrotransposition. Our findings indicate that HMA treatment increases L1‐encoded protein expression but does not lead to detectable de novo retrotransposition events in either patient samples or cell lines.
Šárka Pavlová, Hana Svozilová, Marcela Krzyžánková, Radim Sonnek, Anastasiya Volakhava, Anastasia Smirnova, Tatiana Grigoreva, Zuzana Jašková, Hana Synáčková, Dennis Wahl, Michaela Bilčíková, Libor Červinek, Šárka Pospíšilová, Ilgar Mamedov, Karla Plevová   +14 more
wiley   +1 more source

16. Oktober 1918

, 2018
openaire   +5 more sources

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Nanopore full length 16S rRNA gene sequencing increases species resolution in bacterial biomarker discovery. [PDF]

Sci Rep
Aja-Macaya P, Conde-Pérez K, Trigo-Tasende N, Buetas E, Nasser-Ali M, Nión P, Rumbo-Feal S, Ladra S, Bou G, Mira Á, Vallejo JA, Poza M.   +11 more
europepmc   +1 more source

Screening and Validation of Reference Genes for Normalization of qRT-PCR in Rice BLB Pathogen <i>Xanthomonas oryzae</i> pv. <i>oryzae</i> Under Tetramycin Stress. [PDF]

Genes (Basel)
Fang F, Miao X, Mou T, Wang Z, Guo Y, Yang Y, Gao S, Wang Z, Xu C, Yang J.   +9 more
europepmc   +1 more source

Genetic diversity and phylogeographic relationships of Dermacentor variabilis (Acari: Ixodidae) within an established population in southern Manitoba (Canada), and the prevalence of Rickettsia montanensis and Francisella-like endosymbionts. [PDF]

J Med Entomol
Chilton NB, Thampy PR, Wolbaum CR, Sterling EE, Thoroughgood JT, Berg ED, Halpin AS, Diyes CP, Yunik MEM, Díaz-Sánchez AA, Rochon K, Lysyk TJ, Dergousoff SJ.   +12 more
europepmc   +1 more source

CABO-16S-a Combined Archaea, Bacteria, Organelle 16S rRNA database framework for amplicon analysis of prokaryotes and eukaryotes in environmental samples. [PDF]

NAR Genom Bioinform
Eitel EM, Utter DR, Connon SA, Orphan VJ, Murali R.   +4 more
europepmc   +1 more source