Results 201 to 210 of about 396,782 (350)

Medicago Sativa L. Saponin‐Driven Lactobacillus Intestinalis Restores Intestinal Stemness in Naturally Aged Mice via the Bile Acid‐FXR‐Wnt Signaling Axis

open access: yesAdvanced Science, EarlyView.
This study examines the mechanism by which alfalfa saponin (AS) regulates intestinal stemness via modulation of the gut microbiota. The results indicate that AS significantly increases the abundance of Lactobacillus intestinalis, which subsequently activates Wnt signaling via bile acid metabolism and enhances intestinal stemness. These findings provide
Mengqi Liu   +8 more
wiley   +1 more source

An Engineered Solidified Peptide Hemocyte Sponge as Nanomotor Storage to Combat Bacterial Colitis

open access: yesAdvanced Science, EarlyView.
Peptides immobilized via nickel coordination can stabilize the framework structure. Following coating with red blood cell membranes, these constructs are capable of continuously sequestering endotoxins and mitigating colonic pathogenic damage by alleviating bacterial‐induced ferroptosis.
Yuxin Fang   +8 more
wiley   +1 more source

Lactobacillus Salivarius‐Derived Indole‐3‐Acetic Acid Promotes AHR‐PARP1 Axis‐Mediated DNA Repair to Mitigate Intestinal Aging

open access: yesAdvanced Science, EarlyView.
Indole‐3‐acetic acid (IAA) acting as one of the aryl hydrocarbon receptor (AHR) endogenous ligands is identified to be derived from Lactobacillus salivarius via its catalytic enzyme (ALDH) rather than host cells. Lactobacillus salivarius and IAA supplementation effectively mitigate intestinal aging by facilitating AHR‐poly (ADP‐ribose) polymerase 1 ...
Zheng Cao   +13 more
wiley   +1 more source

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