Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Drug-drug interactions with pioglitazone, losartan, and midazolam and anti-tumor efficacy and safety study of TAS-115 in patients with solid tumors. [PDF]
Cancer Chemother PharmacolKatsuya Y +3 more
europepmc +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Utility of extended HPV genotyping in cervical cancer screening: a prospective population-based cohort study in China. [PDF]
Front OncolYi K +6 more
europepmc +1 more source
An Organoborate Monoxide Radical. [PDF]
J Am Chem SocLi S, Xu G, Luo Y, Li ZH, Lu Z.
europepmc +1 more source
Warning signs for identifying neurodevelopmental disorders: a systematic literature review. [PDF]
J Pediatr (Rio J)Araújo LA.
europepmc +1 more source
Identification of a novel real-time PCR reference gene panel for EA.hy926 endothelial cells in different growth States and with DHA treatment. [PDF]
Sci RepHuang S +5 more
europepmc +1 more source
Lifestyle behaviors, serum metabolites and high myopia: Mendelian randomization and mediation analysis. [PDF]
Int J OphthalmolLiu NE, Xu XT, Yu XB.
europepmc +1 more source