Results 141 to 150 of about 140,614 (262)

Development of Scandium-catalyzed [18F]fluoroalkylation of aniline analogs with [18F]epifluorohydrin under a mild condition

, 2018
Objectives: [18F]Fluoroalkylation is a useful method for introduction of fluorine-18 into molecules containing NH, OH, and SH-groups, analogously to the 11C-methylation with [11C]CH3I.
藤永 雅之, 725126, 藤永, 雅之, 725127   +3 more
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Old disease, new twist

Journal of Hospital Medicine, EarlyView.
Abstract An 81‐year‐old man with a history of high‐grade urothelial carcinoma of the bladder and ureter on treatment with atezolizumab and tiragolumab presented to the emergency department with 5 months of malaise, generalized weakness, and fatigue and 2 weeks of subjective fevers. One month prior to presentation, he received an empiric 9‐day course of
Hadi Roudsari, Gurpreet Dhaliwal, Anand D. Jagannath, Alan H. Baik, Sam Brondfield   +4 more
wiley   +1 more source

Comparison between [18F]fluorination and [18F]fluoroethylation reactions for the synthesis of the PDE10A PET radiotracer [18F]MNI-659

Introduction: 2-(2-(3-(4-(2-[18F]Fluoroethoxy)phenyl)-7-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)-4-isopropoxyisoindoline-1,3-dione ([18F]MNI-659, [18F]1) is a useful PET radiotracer for imaging phosphodiesterase 10A (PDE10A) in human brain.
Hashimoto, Hiroki, Furutsuka, Kenji, Fujinaga, Masayuki, 486356, 486357, 森 若菜, 486354, 486355, Kumata, Katsushi, 486358, 486359, 486360, 河村 和紀, Zhang, Ming-Rong, 古塚 賢士, 486363, 486342, 張 明栄, 486364, 武井 誠, 486361, 486362, Ohkubo, Takayuki, 熊田 勝志, Kawamura, Kazunori, 樋口 真人, 486345, 486346, 486343, 486344, Higuchi, Makoto, 486349, 486347, 大久保 崇之, Muto, Masatoshi, 486348, Takei, Makoto, Tamagnan, Gilles, 橋本 裕輝, 486352, 486353, 藤永 雅之, 武藤 正敏, 486350, Mori, Wakana, 486351   +45 more
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Amyloid‐β–Related Cortical Susceptibility Alterations in Individuals Under Assessment for Alzheimer's Disease: A χ‐Separation Study

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Assessment of amyloid‐β (Aβ) burden and associated iron deposition and neurodegeneration is important for Alzheimer's disease (AD) management. Although quantitative susceptibility mapping (QSM) detects iron and myelin changes, conventional metrics suffer from signal cancelation between paramagnetic and diamagnetic components ...
Hiroyuki Tatekawa, Tatsushi Oura, Akitoshi Takeda, Ayako Omori, Natsuko Atsukawa, Shu Matsushita, Daisuke Horiuchi, Hirotaka Takita, Yasuhito Mitsuyama, Yoshihito Ban, Taro Shimono, Josef Pfeuffer, Daiju Ueda, Yoshiaki Itoh, Yukio Miki   +14 more
wiley   +1 more source

Copper-Mediated Radiofluorination of the Excitatory Amino Acid Transporter 2 (EAAT2)-Targeted PET Tracer [¹⁸F]RP-115: Alternate Synthetic Method. [PDF]

J Labelled Comp Radiopharm
Lee SH, Blecha J, Kim JM, Nillo RM, Flavell RR, Chao CK, Forsayeth JR, Gerdes JM, VanBrocklin HF, Wilson DM.   +9 more
europepmc   +1 more source

Prognostic Value of Combined FDG PET and MRI Analysis of Cervical Cancer: A Systematic Review and Meta‐Analysis

Journal of Medical Radiation Sciences, EarlyView.
This systematic review and meta‐analysis synthesised FDG PET/MRWE biomarkers in cervical cancer, including a pooled analysis of the association between metabolic activity (SUV‐based metrics) and tumour diffusion characteristics (ADC measures). Prognostic evidence from the included studies was also analysed to identify PET‐ and MRI‐based parameters, as ...
William Wei, Dominic Ku, Natalie Rutherford   +2 more
wiley   +1 more source

Imaging [18F]FDG PET/CT pilot study of nicotinic acetylcholinergic receptor α2 knock-out mice and α2 hypersensitive mice compared to control mice: Male-female differences and nicotine effects. [PDF]

PLoS One
Liang C, Tucker TE, Coronel ADL, Nguyen EHN, Nguyen JL, Intskirveli I, Lazar R, Metherate R, Mukherjee J.   +8 more
europepmc   +1 more source

Optimising hypoxia PET imaging and its applications in guiding targeted radiation therapy for non‐small cell lung cancer: a scoping review

Journal of Medical Radiation Sciences, Volume 72, Issue 1, Page 106-118, March 2025.
This review article reports that quantification of hypoxic volumes using PET in the pre‐radiation therapy setting is of prognostic value and indicative of treatment response in non‐small cell lung cancer. Abstract Introduction Non‐small cell lung cancer (NSCLC) is the leading cause of cancer‐related death. Definitive treatment includes chemotherapy and
Carol Marks, Michelle Leech
wiley   +1 more source

Molecular theranostics: principles, challenges and controversies

Journal of Medical Radiation Sciences, Volume 72, Issue 1, Page 156-164, March 2025.
Molecular theranostics offers a powerful tool to drive precision medicine in nuclear oncology. While theranostics is not a new principle in nuclear medicine, recent advances in instrumentation and radiopharmacy have driven a reinvigoration and a broader suite of applications.
Geoffrey Currie
wiley   +1 more source

Radiosynthesis of 18F-fluoroethylated tracers via a simplified one-pot 18F-fluoroethylation method using [18F]fluoroethyl tosylate

Recently, a straightforward one-pot method for 18F-fluoroethylation without azeotropic drying of cyclotron-produced [18F]F– was developed. In this study, we have attempted to simplify the automated radiosynthesis of two [18F]fluoroethylated tracers, [18F ...
Hashimoto, Hiroki, Wakana, Mori, Furutsuka, Kenji, Masanao, Ogawa, Fujinaga, Masayuki, Kumata, Katsushi, 1009298, 1009297, Kazunori, Kawamura, 1009299, Nobuki, Nengaki, Zhang, Ming-Rong, 1009290, Ohkubo, Takayuki, Nengaki, Nobuki, 1009292, 1009291, 1009294, 1009293, 1009296, Ogawa, Masanao, 1009295, Hiroki, Hashimoto, Kawamura, Kazunori, Ming-Rong, Zhang, 1009306, 1009305, Masayuki, Fujinaga, Kenji, Furutsuka, Kurihara, Yusuke, 1009287, 1009286, 1009289, 1009300, 1009288, 1009302, 1009301, 1009304, Mori, Wakana, 1009303, Katsushi, Kumata, 1009285   +41 more
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