Results 191 to 200 of about 119,457 (222)

DSS-PPI: a self-supervised graph learning framework for protein-protein interaction prediction via multimodal sequence semantics. [PDF]

BMC Genomics
Li S, Wang Y, Zhang H, Xing X, Shao Y, Qi Z.   +5 more
europepmc   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Machine learning for identification of restless legs syndrome-associated factors and classification model development in end-stage renal disease patients. [PDF]

Front Neurol
Yuan T, Sun N, Teng L, Xu C, Wang Y, Zhang W, Chang W.   +6 more
europepmc   +1 more source

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

Safety of Adeno-Associated Viral Vectors in Gene Therapy: Mechanisms of Toxicity, Clinical Risks, and Strategies for Their Minimization. [PDF]

Int J Mol Sci
Tsaregorodtseva TS, Radyukhina MA, Ayupova AI, Solovyeva VV, Sufianov AA, Sufianova GZ, Rizvanov AA.   +6 more
europepmc   +1 more source

Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity

Advanced Science, EarlyView.
We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu, Bingwei Wang, Zhijie Su, Xiaoxv Han, Miao He, Yun Zhao, Yujia Hou, Daotong Li, Weiguang Zhang, Lihua Qin, Ke Wang, Yanchun Li, Yi Yan, Siwang Yu, Xiaoshuai Huang, Tairan Yuwen, Jianyuan Luo, Ruimao Zheng   +17 more
wiley   +1 more source

Hybrid machine learning forecasting for resilient and sustainable pharmaceutical supply chains under regulatory and seasonal disruption. [PDF]

Front Artif Intell
Yahya K, Safaei M, Al Dawsari S.
europepmc   +1 more source

Preventing spread of the invasive spotted lanternfly via texture-based automated egg detection. [PDF]

Front Insect Sci
Negrete K, Butler R, Wallis E, Magnani E, Mcglynn MB, McDonald M, Alvarez NJ, Tang M.   +7 more
europepmc   +1 more source

A multicenter, clinically interpretable prediction model for malignancy risk in C-TIRADS 3-4 thyroid nodules. [PDF]

Front Oncol
Liu W, Xie Q, Liu C, Chen B, Yang X, Yang L, Yu H.   +6 more
europepmc   +1 more source