Results 111 to 120 of about 161,336 (310)

Approximation algorithms for the traveling salesman problem

open access: yes, 2002
We first prove that the minimum and maximum traveling salesman problems, their metric versions as well as some versions defined on parameterized triangle inequalities (called sharpened and relaxed metric traveling salesman) are all equi-approximable ...
Monnot, Jérôme   +2 more
core   +3 more sources

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

On the fixed-parameter tractability of the maximum connectivity improvement problem

open access: yes, 2019
In the Maximum Connectivity Improvement (MCI) problem, we are given a directed graph $G=(V,E)$ and an integer $B$ and we are asked to find $B$ new edges to be added to $G$ in order to maximize the number of connected pairs of vertices in the resulting ...
Corò, Federico   +2 more
core   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

open access: yesFEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue   +6 more
wiley   +1 more source

Characterisation of Oil Palm Trunks for Potential Bioenergy Recovery and Utilization

open access: yesProceedings
The cultivation of oil palm (Elaeis guineensis Jaq.) and its production generate large quantities of solid wastes annually. Current strategies adopted for tackling oil palm trunks (OPTs), which account for a significant proportion of oil palm waste (OPW),
Bemgba Bevan Nyakuma   +7 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

open access: yesFEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

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