Results 211 to 220 of about 161,336 (310)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Crowding-out effects of opt-out defaults: Evidence from organ donation policies. [PDF]

PNAS Nexus
Güntürkün P, Studte S, Winkler D, Clement M, Tan JHW, Merz EM, Huis In 't Veld E, Ferguson E.   +7 more
europepmc   +1 more source

SARS-CoV-2 spike protein co-opts VEGF-A/neuropilin-1 receptor signaling to induce analgesia

, 2020
Aubin Moutal, Laurent Martin, Lisa Boinon, Kimberly Gómez, Dongzhi Ran, Yuan Zhou, Harrison J. Stratton, Song Cai, Shizhen Luo, Kerry Beth Gonzalez, Samantha Perez‐Miller, Amol Patwardhan, Mohab Ibrahim, Rajesh Khanna   +13 more
openalex   +1 more source

A Hybrid Space Filling Curve Heuristic with 2-opt for TSP

A Hybrid Space Filling Curve Heuristic with 2-opt for TSP
identifier:oai:t2r2.star.titech.ac.jp ...
openaire  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

A divalent cation-dependent variant of the glmS ribozyme with stringent Ca²⁺ selectivity co-opts a preexisting nonspecific metal ion-binding site [PDF]

, 2016
Matthew Lau, Robert J. Trachman, A.R. Ferré-D′Amaré   +2 more
openalex   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Opinions of the UK general public and stroke survivors in using artificial intelligence and 'opt-out' models of consent in medical research: a qualitative study. [PDF]

BMJ Open
Heseltine-Carp W, Thurtson M, Allen M, Browning D, Courtman M, Kasabe A, Ifeachor E, Mullin S.   +7 more
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Global Evidence of the Unimodal Response of Ecosystem Respiration to Soil Moisture. [PDF]

Adv Sci (Weinh)
Peng J, Xie S, Tang J, Liao J, Chen C, Sun C, Wang Y, Zhou Q, Yu G, Niu S.   +9 more
europepmc   +1 more source