Results 271 to 280 of about 161,336 (310)

Efficient Route Planning in Northeast Thailand Using a Random Shuffle Enhanced 2-opt Algorithm

Kamthorn Sarawan, Pornsiri Khumla
openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

A user-driven consent platform for health data sharing in digital health applications. [PDF]

NPJ Digit Med
Brückner S, Dridi A, Deshmukh A, Kirsten T, Lauber-Rönsberg A, Riedel R, Hetmank S, Welzel C, Gilbert S.   +8 more
europepmc   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Estimating the potential health economic value of introducing universal opt-out testing for HIV in emergency departments in Italy. [PDF]

Eur J Public Health
d'Arminio Monforte A, d'Ettorre G, Galardo G, Lani E, Kagenaar E, Huntington S, Jarrett J, Ruf M, Ricciardi W.   +8 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Genome-Wide Identification of the OPT Gene Family and Screening of Sb-Responsive Genes in <i>Brassica juncea</i>. [PDF]

Plants (Basel)
Liu X, Chen M, Yuan Y, Sheng J, Zhong P, Gong S, Liu Z, Xiang G, Hu J, Yan M, Chen Y, You L.   +11 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Opt-Out Screening for Blood-Borne Viruses in Trauma and Orthopaedic Admissions From the Emergency Department: Are We Meeting the Standards? [PDF]

Cureus
Shahbaz A, Walker M, Imami F, Mahajan U, Shahbaz R, Bose D.   +5 more
europepmc   +1 more source