Results 51 to 60 of about 7,997 (204)

Profiling of HCAR1 signalling reveals Gαi/o and Gαs activation without β‐arrestin recruitment and the discovery of an allosteric agonist

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Lactate, historically viewed as a metabolic by‐product, has emerged as a signalling molecule via the G protein–coupled receptor Hydroxycarboxylic Acid Receptor 1 (HCAR1). The receptor is primarily expressed in adipocytes but also found in various other tissues.
Simon Lind, Shane C. Wright, Emilia Gvozdenovic, Kristina Nilsson, Kenneth L. Granberg, Michel Bouvier, Linda C. Johansson   +6 more
wiley   +1 more source

Comparative evaluation of noncanonical amino acids as site‐specific NMR probes for the complex of E. coli SSB with single‐stranded DNA without isotope labelling

The FEBS Journal, EarlyView.
Genetic encoding of noncanonical amino acids (ncAA) enables their site‐specific installation in proteins. This work compares the nuclear magnetic resonance (NMR) performance of different ncAAs in a large protein−DNA complex (~ 100 kDa) without isotope labelling. The ncAAs deliver readily detectable NMR signals in the complex between E.
Sreelakshmi Mekkattu Tharayil, Haocheng Qianzhu, Elwy H. Abdelkader, Adarshi P. Welegedara, Josemon George, Christoph Nitsche, Thomas Huber, Gottfried Otting   +7 more
wiley   +1 more source

2-Bromopyridines as Versatile Synthons for Heteroarylated 2-Pyridones via Ru(II)-Mediated Domino C–O/C–N/C–C Bond Formation Reactions

Molecules
A novel methodology for the synthesis of 2-pyridones bearing a 2-pyridyl group on nitrogen and carbon atoms, starting from 2-bromopyridines, was developed employing a simple Ru(II)–KOPiv–Na2CO3 catalytic system.
Miha Drev, Helena Brodnik, Uroš Grošelj, Franc Perdih, Jurij Svete, Bogdan Štefane, Franc Požgan   +6 more
doaj   +1 more source

Dichlorido[1-(1,10-phenanthrolin-2-yl)-2-pyridone]cadmium(II)

Acta Crystallographica Section E, 2008
In the title mononuclear complex, [CdCl2(C17H11N3O)], the CdII ion assumes a distorted trigonal–bipyramidal coordination geometry. The pyridone plane is twisted out of the 1,10-phenanthroline mean plane by 43.8 (3)°.
Jin-Min Li
doaj   +1 more source

A study of the effects of exercise on the urinary metabolome using normalisation to individual metabolic output [PDF]

, 2015
Aerobic exercise, in spite of its multi-organ benefit and potent effect on the metabolome, has yet to be investigated comprehensively via an untargeted metabolomics technology.
Anthony, Nahoum, Blackburn, Gavin, Daskalaki, Evangelia, Kalna, Gabriela, Watson, David, Zhang, Tong   +5 more
core   +2 more sources

Asymmetric Negishi and Kumada Couplings

Advanced Synthesis &Catalysis, Volume 368, Issue 5, 3 March 2026.
This review summarizes asymmetric Negishi and Kumada cross‐coupling reactions from the 1980s through 2025. It examines enantioselective and enantiospecific transformations catalyzed by nickel, palladium, and cobalt complexes , highlighting ligand design, mechanistic insights, and applications in constructing complex chiral molecules and natural ...
Rui‐Heng Wang, Aishun Ding, Ramon Rios
wiley   +1 more source

Frame‐Shifted Synthesis of Oligoheterocycles as a Platform for Molecular Design

Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.
Modern chemistry seeks to turn the simple raw materials into complex molecules that matter in health, agriculture, and technology. Among these, oligoheterocycles stand out for their versatility, yet they are most often built by cross‐coupling reactions that often rely on expensive metal catalysts.
Kane A. C. Bastick, Caleb E. Griesbach, Ben Zhen Huang, Morgan J. Cordell, Yang (Daniel) Ou, Alán Aspuru‐Guzik, Andrei K. Yudin   +6 more
wiley   +2 more sources

Dichlorido[1-(1,10-phenanthrolin-2-yl)-2-pyridone]copper(II)

Acta Crystallographica Section E, 2008
In the title mononuclear complex, [CuCl2(C17H11N3O)], the CuII ion is in a distorted square-pyramidal coordination environment. The crystal structure is stabilized by various π–π stacking interactions in which the benzene ring, a pyridine
Jin Min Li
doaj   +1 more source

Nucleophile-Catalyzed Additions to Activated Triple Bonds. Protection of Lactams, Imides, and Nucleosides with MocVinyl and Related Groups [PDF]

, 2014
Additions of lactams, imides, (S)-4-benzyl-1,3-oxazolidin-2-one, 2-pyridone, pyrimidine-2,4-diones (AZT derivatives), or inosines to the electron-deficient triple bonds of methyl propynoate, tert-butyl propynoate, 3-butyn-2-one, N-propynoylmorpholine, or
Adler M., Aggarwal V. K., Alewi B. A., Alonso D. A., Ando K., Anna M. Costa, Ariza X., Baidya M., Balasubramaniam S., Barry C. S., Benohoud M., Bonache M.-C., Broch S., Chatterjee T., Chen H.-G., Costa A. M., Costa A. M., Dandepally S. R., David de Vicente, De Rycke N., Delamarche I., Denes F., Díez-González S., Esteban J., Faja M., Fan M.-J., Foettinger A., Goossen L. J., Goossen L. J., Gorka Etxebarría-Jardí, Hein J. E., Hosokawa T., Janey J. M., Jaume Vilarrasa, Jin S., Joan Font, Joaquim Caner, Kabir M. S., Katz E., Kurosu M., Laura Mola, Lee E., Lee E., Lewis A. F., Liao Y., Lin T. S., Liu Y., Lluís Bosch, Martín R., Matsuya Y., Mayr H., Mekkonen B., Nishimura T., Olivella A., Oriol Pineda, Peshakova L., Pursglove L. A., Ramazani A., Reisman S. E., Robinson R. S., Scheiner P., Seo J. H., Smith N. L., Spychala J., Tejedor D., Tejedor D., Trost B. M., Tyler P. C., Villa M. V. J., Wang J., Yavari I., Ylioja P. M.   +71 more
core   +2 more sources

Dinuclear Rhodium(I)–N‐Heterocyclic Carbene Complexes as Alkyne Hydropyridonation Catalysts

European Journal of Inorganic Chemistry, Volume 29, Issue 7, 2 March 2026.
Catalyst Improvement by NHC tuning: A series of new RhI–NHC dinuclear complexes has been revealed as efficient alkyne hydropyridonation catalysts. 333053IMes complex displays the highest reactivity of the series, suggesting that a moderate steric demand combined with balanced σ‐donation facilitates precatalyst activation and substrate exchange.
Belinda Español‐Sánchez, Mert Olgun Karataş, Andrea Di Giuseppe, Ulugbek Togaev, Vincenzo Passarelli, Luis A. Oro, Jesús J. Pérez‐Torrente, Ricardo Castarlenas   +7 more
wiley   +1 more source