Results 51 to 60 of about 6,930 (204)

Is Mycobacterial InhA a Suitable Target for Rational Drug Design?

ChemMedChem, Accepted Article.
InhA, an NAD‐dependent enoyl‐acyl carrier protein reductase, is involved in the biosynthesis of mycolic acids, specific lipids to mycobacteria. InhA is the target of isoniazid, a first‐line anti‐tuberculosis drug used since the 1950s. Isoniazid is a prodrug that needs to be activated by the catalase‐peroxidase KatG.
Julien Rizet, Laurent Maveyraud, David Rengel, Valérie Guillet, Gabriel Publicola, Frédéric Rodriguez, Christian Lherbet, Lionel Mourey   +7 more
wiley   +1 more source

Deferasirox derivatives as inhibitors of Kallikrein‐related peptidases associated to neurodegenerative diseases

ChemMedChem, Accepted Article.
Kallikrein‐related peptidases are a family of serine proteases which loss of activity regulation has been particularly linked to neurodegenerative diseases. Moreover, iron overload is also a key process in some of these leading pathological conditions, particularly Alzheimer’s disease.
Rilès Boumali, Elodie David, Nancy Chaaya, Morane Lucas, Sabrina AÏT AMIRI, Valérie Lefort, Anthony Nina Diogo, Michèle Salmain, Isabelle Petropoulos, Vincent Corcé, Chahrazade El Amri, Candice Botuha   +11 more
wiley   +1 more source

catena-Poly[[(nitrato-κ2O,O′)silver(I)]-μ3-4-pyridone-κ3O:O:O]

Acta Crystallographica Section E, 2009
In the title complex, [Ag(NO3)(C5H5NO)]n, the AgI atom is coordinated by two O atoms from two different 4-pyridone ligands and two O atoms from one nitrate anion, displaying a nearly planar coordination geometry.
Xian-Ge Wu, Jun-Xia Xiao, Liang Qin
doaj   +1 more source

Catalytic Dehydrogenation of Lauric Acid and a Potential Use in Polyester Synthesis

European Journal of Lipid Science and Technology, EarlyView.
A three‐step reaction sequence was developed to synthesize renewable lauric acid–based dimethyl esters. The sequence consists of a catalytic dehydrogenation of saturated fatty acids with molecular oxygen as oxidant, an esterification with methanol, and a dimerization reaction with dithiols via thia‐Michael addition.
Luis Santos Correa, Emma Stapf, Timo Nonner, Michael A. R. Meier   +3 more
wiley   +1 more source

Design, Synthesis and Anti-fibrosis Activity Study of N1-Substituted Phenylhydroquinolinone Derivatives

Molecules, 2012
Pirfenidone (5-methyl-1-phenyl-2(1H)-pyridone, PFD) is a small-molecule compound acting on multiple targets involved in pathological fibrogenesis and is effective to increase the survival of patients with fibrosis, such as idiopathic pulmonary fibrosis ...
Jun Chen, Lijian Tao, Qianbin Li, Bin Liu, Ling Wu, Gaoyun Hu   +5 more
doaj   +1 more source

Perchloratobis[1-(1,10-phenanthrolin-2-yl)-2-pyridone]zinc(II) perchlorate

Acta Crystallographica Section E, 2009
In the title mononuclear complex, [Zn(ClO4)(C17H11N3O)2]ClO4, the ZnII ion is coordinated in a distorted octahedral geometry. The dihedral angles between the pyridine rings and the mean planes of the 1,10-phenanthroline ring system in each of the 1-(1,10-
Qing Ru Zhao, Qi Sheng Liu, Qing Yun Liu
doaj   +1 more source

One‐Step Aqueous Synthesis of Glycosyl Pyridinium Salts, Electrochemical Study, and Assessment of Utility as Precursors of Glycosyl Radicals Using Photoredox Catalysis

ChemistryOpen, EarlyView.
Unprotected glycosyl pyridinium salts may be accessed in a single step from the corresponding unprotected sugar in aqueous solution. Whilst meta‐ and para‐substitution is well tolerated, ortho substitution of the N‐heterocycle inhibits product formation. Electrochemical studies revealed reduction potentials in the range of −0.9 to −1.4 V.
Daniel Chong, Paula A. Brooksby, Antony J. Fairbanks   +2 more
wiley   +1 more source

Harnessing Molecular and Bioactivity Network Analysis to Prioritize Antibacterial Compound Isolation From Ant‐Associated Fungi

Phytochemical Analysis, EarlyView.
ABSTRACT Introduction Antimicrobial resistance is a global public health problem that requires the development of new bioactive compounds. In this context, metabolomic analyses can expedite the research of fungal metabolites as a valuable resource. Objectives To investigate the metabolic profiles and isolate antibacterial compounds from micromycetes ...
Ángel S. Aguilar‐Colorado, Jesús Morales‐Jiménez, José Rivera‐Chávez   +2 more
wiley   +1 more source

Chemical constitutions in the Colour Index™: A century of colourant classification

Coloration Technology, EarlyView.
Abstract This article details how the Colour Index™ (CI) system categorises and unambiguously labels commercial dyes and pigments based upon their chemical constitutions. It outlines the current process by which colourants that are new to the market find a place within CI and acquire generic identifiers.
Andrew Towns
wiley   +1 more source

Synthesis, structure and solvatochromic properties of some novel 5-arylazo-6-hydroxy-4-phenyl-3-cyano-2-pyridone dyes

Chemistry Central Journal, 2012
Background A series of some novel arylazo pyridone dyes was synthesized from the corresponding diazonium salt and 6-hydroxy-4-phenyl-3-cyano-2-pyridone using a classical reaction for the synthesis of the azo compounds.
Alimmari Adel, Mijin Dušan, Vukićević Radovan, Božić Bojan, Valentić Nataša, Vitnik Vesna, Vitnik Željko, Ušćumlić Gordana   +7 more
doaj   +1 more source