Results 71 to 80 of about 23,419,777 (372)

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

One-year mortality after acute stroke: a prospective cohort study from a comprehensive stroke care centre, Kerala, India

BMJ Open, 2022
Objectives The primary objective was to report the 1-year all-cause mortality among patients with stroke. The secondary objectives were (1) to report the mortality stratified by type of stroke and sex and (2) to report predictors of 1-year mortality ...
Manu Raj, Remya Sudevan, Damodaran Vasudevan, Renjitha Bhaskaran, Vivek Nambiar   +4 more
doaj   +1 more source

SARS2-CoV-2 and Stroke in a New York Healthcare System

Stroke, 2020
Background and Purpose: With the spread of coronavirus disease 2019 (COVID-19) during the current worldwide pandemic, there is mounting evidence that patients affected by the illness may develop clinically significant coagulopathy with thromboembolic ...
S. Yaghi, Koto Ishida, J. Torres, B. M. Mac Grory, E. Raz, Kelley A. Humbert, N. Henninger, Tushar Trivedi, K. Lillemoe, S. Alam, Matthew D Sanger, Sun Kim, E. Scher, S. Dehkharghani, M. Wachs, O. Tanweer, Frank Volpicelli, Brian P. Bosworth, A. Lord, J. Frontera   +19 more
semanticscholar   +1 more source

A Principal Components Analysis Approach to Quantifying Foot Clearance and Foot Clearance Variability [PDF]

, 2019
Low foot clearance and high variability may be related to falls risk. Foot clearance is often defined as the local minimum in toe height during swing; however, not all strides have this local minimum.
Barrett, Barrett, Begg, Begg, Begg, Begg, Borg, Borg, Brandon, Brandon, Byju, Byju, Daffertshofer, Daffertshofer, De Asha, De Asha, Khandoker, Khandoker, Little, Little, Loverro, Loverro, Mills, Mills, Moosabhoy, Moosabhoy, Nagano, Nagano, Nagano, Nagano, Robinovitch, Robinovitch, Santhiranayagam, Santhiranayagam, Santhiranayagam, Santhiranayagam, Savin, Savin, Schulz, Schulz, Schulz, Schulz, Senden, Senden, Sullivan, Sullivan, Thies, Thies, Weinhandl, Weinhandl, Winter, Winter, Zeni, Zeni   +53 more
core   +2 more sources

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Allopurinol use yields potentially beneficial effects on inflammatory indices in those with recent ischemic stroke: a randomized, double-blind, placebo-controlled trial [PDF]

, 2008
<p><b>Background and Purpose</b>: Elevated serum uric acid level is associated with poor outcome and increased risk of recurrent events after stroke.
Dawson, J., Harrow, C., Lees, K.R., Muir, S.W., Sattar, N., Walters, M.R., Weir, C.J.   +6 more
core   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Learning together for better health using an evidence-based Learning Health System framework: a case study in stroke

BMC Medicine
Background In the context of expanding digital health tools, the health system is ready for Learning Health System (LHS) models. These models, with proper governance and stakeholder engagement, enable the integration of digital infrastructure to provide ...
Helena Teede, Dominique A. Cadilhac, Tara Purvis, Monique F. Kilkenny, Bruce C.V. Campbell, Coralie English, Alison Johnson, Emily Callander, Rohan S. Grimley, Christopher Levi, Sandy Middleton, Kelvin Hill, Joanne Enticott   +12 more
doaj   +1 more source

Transglutaminase 2 protects against ischemic stroke

Neurobiology of Disease, 2010
Transglutaminase 2 (TG2) is a multifunctional protein that modulates cell survival and death pathways. It is upregulated in numerous ischemic models, and protects primary neurons from oxygen and glucose deprivation.
A.J. Filiano, J. Tucholski, P.J. Dolan, G. Colak, G.V.W. Johnson   +4 more
doaj   +1 more source

A randomized trial of intraarterial treatment for acute ischemic stroke.

New England Journal of Medicine, 2015
BACKGROUND In patients with acute ischemic stroke caused by a proximal intracranial arterial occlusion, intraarterial treatment is highly effective for emergency revascularization. However, proof of a beneficial effect on functional outcome is lacking.
O. Berkhemer, P. Fransen, D. Beumer, Lucie A van den Berg, Hester F. Lingsma, A. Yoo, W. Schonewille, J. Vos, P. Nederkoorn, M. Wermer, M. V. van Walderveen, J. Staals, J. Hofmeijer, J. V. van Oostayen, G. J. Lycklama à Nijeholt, J. Boiten, P. Brouwer, B. Emmer, S. D. de Bruijn, Lukas C. van Dijk, L. Kappelle, Rob H. Lo, E. V. van Dijk, J. de Vries, P. D. de Kort, W. V. van Rooij, J. V. D. van den Berg, B. V. van Hasselt, L. Aerden, R. Dallinga, M. Visser, J. Bot, P. Vroomen, O. Eshghi, T. Schreuder, R. Heijboer, K. Keizer, A. Tielbeek, H. D. den Hertog, D. Gerrits, R. M. Van den Berg-Vos, G. Karas, E. Steyerberg, H. Z. Flach, H. Marquering, M. Sprengers, S. Jenniskens, L. Beenen, R. van den Berg, P. Koudstaal, W. V. van Zwam, Y. Roos, A. van der Lugt, R. V. van Oostenbrugge, C. Majoie, D. Dippel   +55 more
semanticscholar   +1 more source