Results 161 to 170 of about 13,725,004 (318)

Ancestral Sequence Reconstruction for Novel Bifunctional Glutathione Synthetase with Enhanced Thermostability and Catalytic Efficiency. [PDF]

Foods
Zhao J, Wang B, Di J, Zhou J, Dong J, Ni Y, Han R.   +6 more
europepmc   +1 more source

St Michaels House, OSV-0001827, 20 May 2019

, 2022
Inspection date: 20/05 ...
openaire   +1 more source

Central and peripheral fatigue in male cyclists after 4-, 20-, and 40-km time trials.

Medicine & Science in Sports & Exercise, 2015
Kevin Thomas, S. Goodall, M. Stone, G. Howatson, A. St. Clair Gibson, L. Ansley   +5 more
semanticscholar   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

A dressed singlet-triplet qubit in germanium. [PDF]

Nat Commun
Tsoukalas K, von Lüpke U, Orekhov A, Hetényi B, Seidler I, Sommer L, Kelly EG, Massai L, Aldeghi M, Pita-Vidal M, Hendrickx NW, Bedell SW, Paredes S, Schupp FJ, Mergenthaler M, Salis G, Fuhrer A, Harvey-Collard P.   +17 more
europepmc   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Prevalence, microbiological profiles, and determinants of hospital-acquired pneumonia in Addis Ababa: A focus on Pseudomonas aeruginosa and its antimicrobial resistance patterns in three hospitals. [PDF]

PLoS One
Hailemichael EB, Desta AF, Taye G, Gari SR, Adamu E, Ayenew Z, Amogne W.   +6 more
europepmc   +1 more source

Predictors of outcome in patients with acute coronary syndromes without persistent ST-segment elevation. Results from an international trial of 9461 patients. The PURSUIT Investigators.

Circulation, 2000
Wei-Ching Chang, Kerry L Lee, M. Akkerhuis, M. Simoons, R. Harrington, E. Topol, P. Armstrong, R. Califf, M. Lincoff, K. Pieper, E. Steyerberg, R. Wilcox, J. Deckers, E. Boersma   +13 more
semanticscholar   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source