Results 241 to 250 of about 25,547,481 (294)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Integrated experimental and computational study of a novel indenonaphthodiazepine[5.3.3]propellane as a potential inhibitor of Mcl-1. [PDF]

Nanoscale Adv
Bijarbone SB, Bayat M, Gheidari D.
europepmc   +1 more source

A Low Psoas Muscle Index Was Associated With a Poorer Overall Survival in Patients Who Underwent Percutaneous Nephrostomy

Aging and Cancer, EarlyView.
In patients with malignant ureteral obstruction undergoing percutaneous nephrostomy, sarcopenia defined by a low psoas muscle index was independently associated with poor overall survival on multivariate Cox regression analysis, suggesting that preoperative assessment of psoas muscle index may aid prognostic stratification in this population.
Kota Shimokihara, Takashi Kawahara, Kazuhide Makiyama, Hiroji Uemura   +3 more
wiley   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Reduced-DSP 200G/λ low-voltage slow-light silicon modulator enabled by built-in EO equalizer. [PDF]

Nat Commun
Kawahara K, Tsuchizawa T, Yamamoto N, Maegami Y, Yamada K, Nishiyama N, Baba T.   +6 more
europepmc   +1 more source

Physiological and Transcriptomic Insights into Melatonin-Mediated Alleviation of Cadmium Stress in the Endangered Plant <i>Plantago fengdouensis</i>. [PDF]

Plants (Basel)
Peng Y, Wang BR, Zhang JB, Zuo YW, Liang X, Zhou SM, You SQ, Deng HP.   +7 more
europepmc   +1 more source

Neuroprotective effects of <i>Entandrophragma cylindricum</i> (Meliaceae) extract against "Odontol''-induced cognitive and depressive disorders: An integrated HPLC, molecular docking and experimental validation. [PDF]

IBRO Neurosci Rep
Nadège AOA, Espoir AMR, Ronald BAG, Symphorien MT, Marcelle DB, Ulrich NTJ, Désiré DP.   +6 more
europepmc   +1 more source

Molecular evidence of SARS-CoV-2 detection on cockroaches in Shiraz, southwestern Iran and potential implications for mechanical carriage. [PDF]

Parasite Epidemiol Control
Motevasel M, Vahedi M, Jamalidost M, Kalantari M.   +3 more
europepmc   +1 more source