Results 31 to 40 of about 3,358,507 (237)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
A PRODUÇÃO DO CONHECIMENTO EM EDUCAÇÃO NUM CONTEXTO DE ESTADO DE EXCEÇÃO E INTERDIÇÃO DOS DIREITOS
Holos, 2018 Este texto discute os seguintes pontos: Quais as circunstâncias em que nos encontramos e somos instados a modificá-las para que se desenhe um futuro previsível? O que está subjacente e quais os elementos novos do golpe de Estado de agosto de 2016?
Gaudêncio Frigotto
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source
Journal of Family Medicine and Primary Care, 2022 Background: In India, on an average, 0.5–0.99 kg/person/day general solid waste is produced which is higher (i.e. 0.1–0.49 kg per person per day) than solid waste generated in low-income nations and lower than in developed countries (1.5 kg per day). The
Sukhbir Singh +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo +7 more
wiley +1 more source
Campus universitario de Valladolid: integración urbana y movilidad
Bitácora Urbano Territorial, 2011 La Universidad de Valladolid, vinculada desde sus orígenes a la ciudad que le dio nombre, afronta el reto de replantearse de cara al s. XXI. Fruto esa la vinculación histórica con la ciudad, sus instalaciones se encuentran localizadas de manera dispersa.
Juan Luis De las Rivas Sanz +2 more
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