Results 111 to 120 of about 26,157,229 (388)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Revista de Ciências do Estado, 2021 Este ensaio visa a oferecer uma imagem da sociedade brasileira neste momento, desde os eventos de junho de 2013 até a presente crise sob o governo Bolsonaro.
David Francisco Lopes Gomes
doaj
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
ANALYSIS OF THE EFFECTIVENESS OF PB DJARUM ADVERTISING SCHOLARSHIP USING THE EPIC METHOD IN 2020
, 2021 Muhammad Abdul Muis +2 more
openalex +2 more sources
Spartan Daily, March 26, 2020 [PDF]
, 2020 Volume 154, Issue 28https://scholarworks.sjsu.edu/spartan_daily_2020/1027/thumbnail ...
San Jose State University, School of Journalism and Mass Communications
core +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Strategi Meningkatkan Partisipasi Masyarakat Dalam Pilkada Serentak 2020 di Masa Pandemi Covid-19
, 2021 Salsabila Yumna Fadhila, Dewi Erowati
openalex +2 more sources
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source