Results 41 to 50 of about 4,146,693 (295)

Ensaios sobre a pluralidade epistemológica da Geografia na escola

Perspectiva, 2022
Em seu âmago, a Educação Geográfica constitui-se como conhecimento que estrutura a leitura do mundo, cumprindo uma função social importante, ao possibilitar múltiplas formas de compreender a realidade dos lugares onde se vive e das relações entre a ...
Kalina Salaib Springer, Rosemy da Silva Nascimento, Francisco de Assis Gonçalves Junior   +2 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

17º Congreso Internacional de Anticuerpos Antifosfolípidos 2022

Revista Argentina de Reumatología, 2022
Este suplemento de la Revista de la Sociedad Argentina de Reumatología ofrece todos los resúmenes presentados durante ICAPA 2022. Durante casi 2 años la pandemia del COVID-19 demandó importantes esfuerzos para mantener la investigación clínica y básica ...
Comité Ejecutivo Internacional, Comité Científico, Comité de Planificación Local, Comité de Enlace, Equipo Editorial   +4 more
doaj  

Introduction pages, Notulae Scientia Biologicae 14(4), 2022

Notulae Scientia Biologicae, 2022
Notulae Scientia Biologicae (http://www.notulaebiologicae.ro), Issue 4, Volume 14, 2022: The papers published in this issue represent interesting novelties in different topics of life science. Among the exciting research or reviews, we invite readers to
Radu E. SESTRAS
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Analysis of articles in the Journal of Archives of Academic Emergency Medicine in 2022

Archives of Academic Emergency Medicine, 2022
In 2022, Archives of Academic Emergency Medicine (AAEM) has published 90 articles, all of which are indexed by SCOPUS, Web of Sciences, PubMed and some other databases. They have been authored by more than four hundred researchers from various countries,
Somayeh Saghaei Dehkordi, Mehrnoosh Yazdanbakhsh   +1 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Factors associated with HIV-positive status among men who have sex with men in Guinea in 2022

Frontiers in Public Health
Introduction/Context Men who have sex with men (MSM) continue to carry a disproportionate burden of HIV in West and Central Africa, where stigma, criminalization, and legal restrictions hinder access to essential prevention and treatment services.
Mamadou Samba Dioum, Septime Hessou, Tamba Mina Millimouno, Tamba Mina Millimouno, Fassou Mathias Grovogui, Delphin Kolié, Thierno Saidou Diallo, Elhadji Mamadou Dioukhane, Elhadj Marouf Diallo, Alioune Camara, Thierno Mamadou Tounkara, Alexandre Delamou, Alexandre Delamou, Fodé Bangaly Sako   +13 more
doaj   +1 more source