Results 131 to 140 of about 14,235,430 (340)

Explicit and implicit methods for second order ordinary differential equations [PDF]

, 1980
A family of explicit formulas is developed for solving a system of second order linear ordinary differential equations with constant coefficients and with initial conditions specified.
Twizell, E H
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

PCA-based synthetic sensitivity coefficients for chemical reaction network in cancer

Scientific Reports
Chemical reaction networks are powerful tools for modeling cell signaling and its disruptions in diseases like cancer. Realistic chemical reaction networks involve hundreds of proteins and reactions, resulting in a model depending on a consistently large
Giorgia Biddau, Giacomo Caviglia, Michele Piana, Sara Sommariva   +3 more
doaj   +1 more source

2023 ESC Guidelines for the management of cardiovascular disease in patients with diabetes.

European Heart Journal, 2023
Nikolaus Marx, M. Federici, K. Schütt, D. Müller-Wieland, R. Ajjan, M. Antunes, R. Christodorescu, Carolyn B Crawford, E. di Angelantonio, B. Eliasson, C. Espinola-Klein, L. Fauchier, Martin Halle, W. Herrington, A. Kautzky-Willer, E. Lambrinou, M. Lesiak, M. Lettino, Darren K Mcguire, W. Mullens, B. Rocca, N. Sattar   +21 more
semanticscholar   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Agua y energía: la disputa por la soberanía en Paraguay. Entrevista a Sara Costa

Relaciones Internacionales, 2020
Agua y energía: la disputa por la soberanía en Paraguay. Entrevista a Sara Costa.
Eduardo Tamayo Belda
doaj  

Managing Human Resources in Higher Education: The Implications of a Diversifying Workforce [PDF]

, 2007
Human resource capacity has become a critical issue for contemporary universities as a result of increasing pressures from governments and global markets.
Gordon, George, Whitchurch, Celia
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

ERRATUM (An erratum has been prepared for the following articles in the 33rd volume and 2nd issue of Current Research in Dental Sciences in 2023.)

Current Research in Dental Sciences
Erratum An erratum has been prepared for the following articles in the 33rd volume and 2nd issue of Current Research in Dental Sciences in 2023. - In the article titled "Özyurt E, Kurt A.
Erratum E.
doaj   +1 more source