Results 101 to 110 of about 96,380 (331)

Alterations in gut microbiota and metabolites contribute to postoperative sleep disturbances

Animal Models and Experimental Medicine, EarlyView.
In this study, we classified postoperative patients into poor sleepers (PS) and good sleepers (GS) based on the bispectral index (BIS), and transplanted their fecal microbiota to pseudo‐germ‐free rats to analyze the sleep changes in rats and the potential mechanism.
Hui Zhong, Meiru Jiang, Kun Yuan, Fang Sheng, Xiuyun Xu, Yong Cui, Xijia Sun, Wenfei Tan   +7 more
wiley   +1 more source

Management of 21 hydroxylase deficiency salt-wasting form of congenital adrenal hyperplasia

Sri Lanka Journal of Diabetes Endocrinology and Metabolism, 2012
 DOI: http://dx.doi.org/10.4038/sjdem.v1i1.4186 Sri Lanka Journal of Diabetes Endocrinology and Metabolism 2011; 1: 28-29   
KSH de Silva
doaj   +1 more source

Update: Enzymatische Synthese für industrielle Anwendungen

Angewandte Chemie, EarlyView.
Die Biokatalyse hat sich zu einer nachhaltigen und wettbewerbsfähigen Alternative zur herkömmlichen chemischen Synthese entwickelt und ermöglicht die enzymbasierte Herstellung nicht nur von chemischen Grundstoffen, sondern auch von (nicht natürlichen) Aminosäuren, (seltenen) Zuckern und synthetischen Nukleotiden.
Thomas Bayer, Shuke Wu, Radka Snajdrova, Kai Baldenius, Uwe T. Bornscheuer   +4 more
wiley   +1 more source

Increased mortality in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency [PDF]

, 2017
Context: Reports on mortality in patients with congenital adrenal hyperplasia (CAH) are lacking. Objective: To study mortality and causes of death in CAH.
Almqvist, C., Falhammar, H., Frisén, L., Linden Hirschberg, A., Nordenskjöld, A., Nordenström, A., Norrby, C.   +6 more
core   +1 more source

Neonatal mass screening for 21-hydroxylase deficiency

Clinical Pediatric Endocrinology, 2016
Congenital adrenal hyperplasia(CAH)due to 21-hydroxylase deficiency (21-OHD) is an inherited autosomal recessive disorder. Its incidence is 1 in 10,000 to 20,000 worldwide. This disease shows phenotypic differences, and it is divided into three forms i.e., the salt wasting (SW), simple virilizing (SV), and nonclassic (NC) forms. The most severe form of
Toshihiro Tajima, Masaru Fukushi
openaire   +4 more sources

CYP21 gene mutations in Brazilian patients with 21-hydroxylase deficiency from the Amazon region

Genetics and Molecular Biology, 2008
Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (P450c21, CYP21) accounts for about 95% of all CAH cases. The incidence of CYP21 gene mutations has been extensively studied in the last years, but in Brazil it has been investigated ...
Tarcísio André Amorim de Carvalho, Izabel Cristina Neves de Souza, France Keiko Nascimento Yoshioka, Milena Coelho Fernandes Caldato, Nilza Nei Torres, Lena Stilianidi Garcia, João Farias Guerreiro   +6 more
doaj   +1 more source

The "backdoor pathway" of androgen synthesis in human male sexual development. [PDF]

, 2019
Mammalian sex determination (male versus female) is largely controlled by genes, whereas sex differentiation (development of reproductive structures) is largely controlled by hormones. Work in the 20th century indicated that female external anatomy was a
Auchus, Richard J, Miller, Walter L
core   +2 more sources

Thiotemplated Polyketide Chain Fusion and Reductive Cyclization Build the Reactive Butenolide Core of Malleicyprol

Angewandte Chemie International Edition, Accepted Article.
Malleicyprol, a virulence factor of notorious animal and human pathogens of the Burkholderia pseudomallei (BP) group, features a molecular cyclopropanol warhead linked to a reactive butenolide core. Biosynthetic considerations suggested that this heterocycle was formed by the merger of two individual polyketide chains, but the precise mechanism has ...
Jonas Fiedler, Leo Dumjahn, Ishida-Ito Mie, Felix Trottmann, Keishi Ishida, Christian Hertweck   +5 more
wiley   +1 more source

Polymorphism of the tumor necrosis factor beta gene in systemic lupus erythematosus [PDF]

, 1993
We investigated the Nco I restriction fragment length polymorphism (RFLP) of the tumor necrosis factor beta (TNFB) gene in 173 patients with systemic lupus erythematosus (SLE), 192 unrelated healthy controls, and eleven panel families, all of German ...
Albert, E. D., Bettinotti, M. P., Deicher, H., Hartung, K., Keller, E., Messer, Gerald, Weiss, Elisabeth H.   +6 more
core   +1 more source

An Update: Enzymatic Synthesis for Industrial Applications

Angewandte Chemie International Edition, EarlyView.
Biocatalysis has become a sustainable and cost‐competitive alternative to established chemical synthesis, enabling the enzyme‐based production of not only commodity chemicals but (non‐natural) amino acids, (rare) sugars, as well as synthetic nucleotides.
Thomas Bayer, Shuke Wu, Radka Snajdrova, Kai Baldenius, Uwe T. Bornscheuer   +4 more
wiley   +1 more source