Alterations in gut microbiota and metabolites contribute to postoperative sleep disturbances
Animal Models and Experimental Medicine, EarlyView.In this study, we classified postoperative patients into poor sleepers (PS) and good sleepers (GS) based on the bispectral index (BIS), and transplanted their fecal microbiota to pseudo‐germ‐free rats to analyze the sleep changes in rats and the potential mechanism.
Hui Zhong +7 more
wiley +1 more source
Management of 21 hydroxylase deficiency salt-wasting form of congenital adrenal hyperplasia
Sri Lanka Journal of Diabetes Endocrinology and Metabolism, 2012 DOI: http://dx.doi.org/10.4038/sjdem.v1i1.4186 Sri Lanka Journal of Diabetes Endocrinology and Metabolism 2011; 1: 28-29
KSH de Silva
doaj +1 more source
Guidelines for diagnosis and treatment of 21-hydroxylase deficiency (2014 revision)
Clinical Pediatric Endocrinology, 2015 Purpose of developing the guidelines: The first guidelines for diagnosis and treatment of 21-hydroxylase deficiency (21-OHD) were published as a diagnostic handbook in Japan in 1989, with a focus on patients with severe disease.
T. Ishii +13 more
semanticscholar +1 more source
GADA titer-related risk for organ-specific autoimmunity in LADA subjects subdivided according to gender (NIRAD study 6). [PDF]
, 2012 CONTEXT: Latent autoimmune diabetes in adults (LADA) includes a heterogeneous population wherein, based on glutamic acid decarboxylase antibody (GADA) titer, different subgroups of subjects can be identified.
Bosi, E +11 more
core +1 more source
Journal of Clinical Endocrinology and Metabolism, 2015 CONTEXT Childhood obesity rates in congenital adrenal hyperplasia (CAH) exceed the high rates seen in normal children, potentially increasing their risk of cardiovascular disease (CVD). Abdominal adiposity, in particular visceral adipose tissue (VAT), is
Mimi S. Kim +6 more
semanticscholar +1 more source
CYP21 gene mutations in Brazilian patients with 21-hydroxylase deficiency from the Amazon region
Genetics and Molecular Biology, 2008 Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (P450c21, CYP21) accounts for about 95% of all CAH cases. The incidence of CYP21 gene mutations has been extensively studied in the last years, but in Brazil it has been investigated ...
Tarcísio André Amorim de Carvalho +6 more
doaj +1 more source
Journal of Clinical Endocrinology and Metabolism, 2014 CONTEXT Reports on psychiatric morbidity in males with congenital adrenal hyperplasia (CAH) are lacking. OBJECTIVE The aim was to study psychiatric disorders in CAH males.
H. Falhammar +6 more
semanticscholar +1 more source
Adrenal crises: perspectives and research directions [PDF]
, 2017 Adrenal crises (AC) are life-threatening complications of adrenal insufficiency (AI). These events have an estimated incidence of between 5 and 10 ACs/100 patient years (PY) and are responsible for some of the increased morbidity and excess mortality ...
Falhammar, H, Rushworth, R, Torpy, D
core +2 more sources
Normal sex differences in prenatal growth and abnormal prenatal growth retardation associated with 46,XY disorders of sex development are absent in newborns with congenital adrenal hyperplasia due to 21-hydroxylase deficiency [PDF]
, 2011 Background Congenital adrenal hyperplasia due to 21-hydroxylase deficiency is the most common presentation of a disorder of sex development (DSD) in genetic females. A report of prenatal growth retardation in cases of 46,XY DSD, coupled with observations
Bright, Brianna C +5 more
core +3 more sources
Abiraterone acetate to lower androgens in women with classic 21-hydroxylase deficiency.
Journal of Clinical Endocrinology and Metabolism, 2014 CONTEXT Chronic supraphysiological glucocorticoid therapy controls the androgen excess of 21-hydroxylase deficiency (21OHD) but contributes to the high prevalence of obesity, glucose intolerance, and reduced bone mass in these patients.
R. Auchus +11 more
semanticscholar +1 more source