Therapeutic targeting of chromatin alterations in leukemia and solid tumors
International Journal of Cancer, EarlyView.Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner +7 more
wiley +1 more source
Vitamin D deficiency in a subfertility population and the impact of COVID‐19 lockdowns
International Journal of Gynecology &Obstetrics, EarlyView.Abstract Objective To evaluate the burden of vitamin D deficiency in female patients attending a fertility clinic in a tertiary referral center, assess temporal trends—including the potential impact of COVID‐19 lockdowns—and explore socioeconomic disparities in vitamin D levels.
Catherine M. Windrim +3 more
wiley +1 more source
46,XX males with congenital adrenal hyperplasia: a clinical and biochemical description
Frontiers in EndocrinologyIntroductionCongenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21OHD) or 11-hydroxylase deficiency (11OHD) is characterized by underproduction of cortisol and overproduction of adrenal androgens.
Bas P. H. Adriaansen +15 more
doaj +1 more source
Genesis by meiotic unequal crossover of a de novo deletion that contributes to steroid 21-hydroxylase deficiency. [PDF]
, 1990 P. J. Sinnott +5 more
openalex +1 more source
Synthetic biology for medical biomaterials
Interdisciplinary Medicine, EarlyView.Synthetic biology platform has been utilized to produce a variety of medical biomaterials (MBMs), such as polylactic acid (PLA), polyhydroxyalkanoates (PHAs), hyaluronic acid (HA), collagen (COL), poly(β‐malic acid) (PMLA), poly‐γ‐glutamic acid (γ‐PGA), alginate (ALG), chitosan (CS), bacterial cellulose (BC), and antimicrobial peptides (AMPs).
Tao Xu +4 more
wiley +1 more source
Adrenal and Testicular Tumor Formation Due to 21-Hydroxylase Deficiency [PDF]
, 2022 Honda, Hiroyuki +2 more
core +1 more source
Identification of promoter elements in the mouse 21-hydroxylase (Cyp21) gene that require a functional cyclic adenosine 3',5'-monophosphate-dependent protein kinase. [PDF]
, 1993 Amadeo M. Parissenti +2 more
openalex +1 more source
Journal of Biophotonics, EarlyView.In this article, we present 3D‐LIMPID‐FISH: a simple and fast optical clearing method for acquiring 3D images of fluorescence in situ hybridization probes. Figures and movies are provided to showcase the technology, and a detailed protocol is provided to replicate the result.
Junwoo Suh +5 more
wiley +1 more source
Glucocorticoid regulation of diurnal spine plasticity in the murine ventromedial prefrontal cortex
Journal of Neuroendocrinology, Volume 34, Issue 12, December 2022., 2022 In mice, the core clock gene Per1 is expressed rhythmically within the ventromedial prefrontal cortex (vmPFC). Deep layer pyramidal neurons within the vmPFC exhibit a diurnal rhythm of dendritic spine density. Both Per1 expression and dendritic spine density are increased during the active phase along with the diurnal peak of glucocorticoid (GC ...
Alex M. Miller +4 more
wiley +1 more source