We conducted a comprehensive investigation of the metabolic profiles of infiltrating T cells in NSCLC tumors and found metabolic heterogeneity in three T‐cell subtypes, which are associated with the prognosis of ICB therapy. We defined these metabolic clusters as response‐dependent (R) clusters and non‐response‐dependent (NR) clusters, and elucidated ...
Hongzhe Guo+7 more
wiley +1 more source
Abstract BACKGROUND The production of compatible solutes, such as ectoine and hydroxyectoine, is of great interest due to their industrial and biotechnological applications. Methylomicrobium alcaliphilum was genetically engineered to replace a native gene with a heterologous one, aiming to enhance ectoine production.
Raquel Herrero‐Lobo+7 more
wiley +1 more source
SLUGGISH RESPONSE TO ADRENOCORTICOTROPIN STIMULATION IN NEWBORNS WITH 21-HYDROXYLASE DEFICIENCY (CAH) [PDF]
G Kalaitzoqlou, Maria I. New
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Sensory and Autonomic Fibers in Anterior Ethmoid, Posterior Nasal, Posterolateral Nasal Nerves
All cadaveric anterior ethmoid, posterior, and posterolateral nasal nerves contained roughly equivalent proportions of sensory, parasympathetic, and sympathetic nerve fiber markers. Neurokinin A was the only neuropeptide with consistently greater percent areas across the different nasal nerves.
John R. Craig+6 more
wiley +1 more source
Biphasic regulation by N6, 2′-O-dibutyryl adenosine 3′, 5′-cyclic monophosphate (dbcAMP) of steroid 21-hydroxylase activity in rat hepatocytes [PDF]
Kaoru Nasuda+2 more
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Abstract Cyclodepsipeptides (CDPs) represent a huge family of chemically and structurally diverse molecules with a wide ability for molecular interactions. CDPs are cyclic peptide‐related natural products made up of both proteinogenic and nonproteinogenic amino acids linked by amide and ester bonds.
Sophie Liuu+10 more
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Editorial: Recent advances in diagnosis and treatment of congenital adrenal hyperplasia due to 21-hydroxylase deficiency. [PDF]
Çaglar Çetinkaya S.
europepmc +1 more source
Neonatal Screening for Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency
Masaru Fukushi+5 more
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Steroid 21-Hydroxylase Autoantibodies: Measurements with a New Immunoprecipitation Assay1 [PDF]
Hideaki Tanaka+11 more
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Myoclonic Dystonia: A Common Phenomenology in the Pleomorphic Movements of Angelman Syndrome
Abstract Background Angelman syndrome (AS) is a neurodevelopmental disorder characterized by developmental delay, intellectual disability, a sociable demeanor, and abnormal movements. People with AS often exhibit multiple types of abnormal movements, including nonepileptic myoclonus, tremor, and dystonia, which hamper attempts to identify phenomenology
Robert P. Carson+8 more
wiley +1 more source