Results 261 to 270 of about 2,389,640 (367)

Adrenocortical hyperresponsivity to adrenocorticotropic hormone: a mechanism favoring the normal production of cortisol in 21-hydroxylase-deficient nonclassic adrenal hyperplasia [PDF]

, 2000
Raquel Huerta, Didier Dewailly, Christine Decanter, Eric S. Knochenhauer, Larry R. Boots, Ricardo Azziz   +5 more
openalex   +1 more source

Targeting Regulation of Macrophage to Treat Metabolic Disease: Role of Phytochemicals

Cell Proliferation, EarlyView.
One‐third of the world's population is affected by metabolic syndrome. Complicated pathogenesis and limited drugs cause the growing prevalence of metabolic syndrome. Macrophage‐mediated metaflammation is closely associated with the development of metabolic syndrome. The role of phytochemicals targeting macrophages in the treatment of metabolic syndrome
Zeting Ye, Yanlin Li, Xiaolin Yang, Chenglin Li, Rui Yu, Guangjuan Zheng, Zuqing Su   +6 more
wiley   +1 more source

Nonclassic congenital adrenal hyperplasia due to 21-hydroxylase deficiency in women: diagnosis and treatment: Number 11 - 2024. [PDF]

Rev Bras Ginecol Obstet
Nácul AP, Silva ACJSRE, Yela DA, de Medeiros SF, Soares JM, Antoniassi GPR, Damásio LCDC, Maranhão TMO, Maciel GAR, Benetti-Pinto CL.   +9 more
europepmc   +1 more source

Rapid screening method to detect mutations inCYP21, the gene for 21-hydroxylase [PDF]

, 2000
Yuji Yokoyama, Michio Teraoka, Kazushiro Tsuji, Shinsuke Ninomiya, Chiyo Inoue, S. Yamashita, K Narahara, Yoshiki Seino   +7 more
openalex   +1 more source

Rapid and Effective Neuronal Conversion of Human Glioblastoma In Vitro and In Vivo Using Potent Small Molecules

Cell Proliferation, EarlyView.
A potent combination of small molecules YFSS (Y27632, Forskolin, SB431542, SP600125) that were screened through a neuronal‐specific promoter–reporter system TUBB3::mCherry effectively induces neuronal‐GBM conversion in vitro and in vivo, unveiling molecular mechanisms that offer a theoretical basis and a potential therapeutic strategy for treating GBM.
Ya'nan Hu, Jinming Liu, Jian Tu, Min Yang, Qisheng He, Fei Li, Xiaojing Xu, Zhongqing Ji, Jianwei Xu, Wentao Zhong, Mengwen Yan, Ying Yang, Huanxiang Zhang   +12 more
wiley   +1 more source

Novel rapid molecular diagnosis methods for comprehensive genetic analysis of 21-hydroxylase deficiency. [PDF]

Orphanet J Rare Dis
Xia Y, Yu F, Bai Y, Jiang L, Shi P, Jiang Z, Kong X.   +6 more
europepmc   +1 more source

Bioavailability of oral hydrocortisone in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency [PDF]

, 2001
Evangelia Charmandari, A. E. Johnston, C.G.D. Brook, PC Hindmarsh   +3 more
openalex   +1 more source

A review of the putative antiseizure and antiepileptogenic mechanisms of action for soticlestat

Epilepsia, EarlyView.
Abstract Soticlestat (TAK‐935) is a potent and selective inhibitor of cholesterol 24‐hydroxylase (CYP46A1), an enzyme primarily expressed in the brain that catabolizes cholesterol to 24S‐hydroxycholesterol (24HC). In the ELEKTRA phase II clinical trial, soticlestat reduced seizure frequency in patients with developmental and epileptic encephalopathies,
Shinichi Kondo, Venkatesha Murthy, Mahnaz Asgharnejad, Arturo Benitez, Kosuke Nakashima, Nicole Hawkins, H. Steve White   +6 more
wiley   +1 more source

Longitudinal analysis of growth and puberty in 21-hydroxylase deficiency patients [PDF]

, 2002
Buitenweg, N., de Muinck Keizer-Schrama, S.M.P.F., Delemarre-de Waal, H.A., Oostdijk, W., Otten, B.J., van der Kamp, H.J., Vulsma, T., Wit, J.M.   +7 more
core   +1 more source

Antenatal Diagnosis and Treatment in Congenital Adrenal Hyperplasia Due to 21-hydroxylase Deficiency and Congenital Adrenal Hyperplasia Screening in Newborns [PDF]

J Clin Res Pediatr Endocrinol
Yavaş Abalı Z, Kurnaz E, Güran T.
europepmc   +1 more source