Results 71 to 80 of about 34,531 (209)
C. elegans fatty acid two-hydroxylase regulates intestinal homeostasis by affecting heptadecenoic acid production [PDF]
, 2018 Background/Aims: The hydroxylation of fatty acids at the C-2 position is the first step of fatty acid α-oxidation and generates sphingolipids containing 2-hydroxy fatty acyl moieties.
Fu, Rong +10 more
core +3 more sources
Research progress on the mechanisms of pain empathy
Ibrain, EarlyView.This article is related to the graphical research progress of pain empathy, starting with the description of the pain matrix and mirror neurons. Based on the pain matrix and mirror neurons, pain empathy results from the combined action of brain regions such as the anterior cingulate cortex, insula, prefrontal cortex, and amygdala and regulatory ...
Shuangshuang Liu +5 more
wiley +1 more source
Coenzyme Q10 deficiencies: pathways in yeast and humans. [PDF]
, 2018 Coenzyme Q (ubiquinone or CoQ) is an essential lipid that plays a role in mitochondrial respiratory electron transport and serves as an important antioxidant.
Awad, Agape M +5 more
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Therapeutic targeting of chromatin alterations in leukemia and solid tumors
International Journal of Cancer, EarlyView.Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner +7 more
wiley +1 more source
Classic virilizing congenital adrenal hyperplasia presenting late: case series from Pakistan [PDF]
, 2009 Deficiency of 21 hydroxylase enzyme deficiency (21OH) activity accounts for 90% cases of congenital adrenal hyperplasia (CAH). This results in deficient cortisol, increased ACTH, adrenal hyperplasia and increased adrenal androgen secretion.
Aban, Muniba +6 more
core +1 more source
Vitamin D deficiency in a subfertility population and the impact of COVID‐19 lockdowns
International Journal of Gynecology &Obstetrics, EarlyView.Abstract Objective To evaluate the burden of vitamin D deficiency in female patients attending a fertility clinic in a tertiary referral center, assess temporal trends—including the potential impact of COVID‐19 lockdowns—and explore socioeconomic disparities in vitamin D levels.
Catherine M. Windrim +3 more
wiley +1 more source
Hypospadias in a Male Patient with 21-hydroxylase Deficiency
Endocrine Journal, 2008 A 17-day-old Japanese boy was transferred to the hospital because of vomiting and impaired consciousness. His external genitalia was pigmented associated with small penis and penoscrotal hypospadias. He was diagnosed as suffering from adrenal deficiency according to severe electrolyte abnormality, moderate hypoglycemia, metabolic acidosis and extremely
Eishin Ogawa +5 more
openaire +4 more sources
iMeta, EarlyView.A single‐cell atlas was established to reveal the molecular characteristics of early gastric cancer (EGC). In combination with organoids, animal models, and clinical samples, it was found that subpopulations such as pit mucous‐like cell (PMC‐like), proliferating cell (PC), CH25H+ CD4+ T cell, IL‐33+ endothelial cell, and ADAMTSL2+ endothelial cell are ...
Li Zhou +15 more
wiley +1 more source
Synthetic biology for medical biomaterials
Interdisciplinary Medicine, EarlyView.Synthetic biology platform has been utilized to produce a variety of medical biomaterials (MBMs), such as polylactic acid (PLA), polyhydroxyalkanoates (PHAs), hyaluronic acid (HA), collagen (COL), poly(β‐malic acid) (PMLA), poly‐γ‐glutamic acid (γ‐PGA), alginate (ALG), chitosan (CS), bacterial cellulose (BC), and antimicrobial peptides (AMPs).
Tao Xu +4 more
wiley +1 more source
Single-Cell RNA-seq Reveals Profound Alterations in Mechanosensitive Dorsal Root Ganglion Neurons with Vitamin E Deficiency. [PDF]
, 2019 Ninety percent of Americans consume less than the estimated average requirements of dietary vitamin E (vitE). Severe vitE deficiency due to genetic mutations in the tocopherol transfer protein (TTPA) in humans results in ataxia with vitE deficiency (AVED)
Bordbari, Matthew H +9 more
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