Results 151 to 160 of about 42,411 (250)

Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects

Advanced Science, EarlyView.
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu, Ke Wang, Kaizhong Lu, Tianlun Hou, Yuan Chen, Xian Wang, Hongchuan Jin   +6 more
wiley   +1 more source

Huldiging of vermaning? De voorstellingen van Hercules am scheidewege (BWV 213) van J.S. Bach en La clemenza di tito (KV 621) van W.A. Mozart

, 2002
H.B.T. Schot
openalex   +1 more source

Full‐Stack Architectures for Intelligent Brain‐Computer Interfaces

Advanced Science, EarlyView.
System‐level overview of brain–computer interfaces (BCIs), illustrating the integration of neural signal acquisition, wireless transmission, and adaptive decoding. Advanced electrode, tissue interfaces, energy‐efficient communication, and robust algorithms collectively enable stable signal quality, real‐time processing, and closed‐loop operation ...
Hee Kyu Lee, Hyun Bin Kim, Sang Uk Park, Janghoon Joo, Jinhong Min, Geumbee Lee, Joohoon Kang, Hyoyoung Jeong, Jae‐Young Yoo, Sang Min Won   +9 more
wiley   +1 more source

Esther Fischer-Homberger, Geschichte der Medizin (Heidelberger Taschenbuicher,Basistext Medizin), Berlin, Heidelberg and New York, Springer-Verlag, 1975, pp. viii, 213, illus., [no price stated]. [PDF]

, 1976

openalex   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

PDIA6–SCD1 Axis Rewires Lipid Metabolism to Drive Gastric Cancer Progression

Advanced Science, EarlyView.
Protein disulfide isomerase A6 (PDIA6) is identified as an oncogenic driver in gastric cancer. PDIA6 directly binds and stabilizes SCD1 by limiting its ubiquitin–proteasome‐mediated degradation, thereby sustaining monounsaturated fatty acid (MUFA)‐enriched lipid homeostasis and lipid metabolic reprogramming.
Zhen Tian, Yifan Cheng, Jiajie Zhou, Ruiqi Li, Shuai Zhao, Ben Li, Zijie Xu, Mengli Zi, Yayan Fu, Chenkai Zhang, Qiannan Sun, Shantanu Baral, Sen Wang, Daorong Wang   +13 more
wiley   +1 more source

Sebaceous Carcinoma: A Retrospective Multicenter Analysis of 213 Cases [PDF]

Sebastian A. Wohlfeil, Jochen S. Utikal, Christiane Bauer‐Auch, Irina Surovtsova, Tilo Vogel, Anna‐Lena Koy, Philipp Morakis   +6 more
openalex   +1 more source

Molecular Mobility of N‐Acetylgalactosamine‐Modified Cyclodextrins on a Polyrotaxane for Highly Efficient Liver Targeting of Antibody Chimeras and Genome‐Editing Ribonucleoproteins

Advanced Science, EarlyView.
Monovalent N‐acetylgalactosamine (GalNAc)‐modified polyrotaxane enables efficient liver targeting by utilizing ligand mobility. The sliding and rotating cyclic components i.e., cyclodextrin in the polyrotaxane dynamically cluster GalNAc moieties, thereby mimicking trivalent interactions with asialoglycoprotein receptors.
Toru Taharabaru, Keiichi Motoyama, Yuting Wen, Zhongxing Zhang, Xuehao Tian, Jun Li, Taishi Higashi   +6 more
wiley   +1 more source

Figure 6 from: Supapongsri V, Sahathippayakul A, Sirisarn W, Chand M, Chou J-Y, Lueangjaroenkit P (2025) Two new species of Penicillium (Eurotiales, Aspergillaceae) and the first record of P. danzhouense from mangrove sediment in Thailand, with notes on antibacterial activity. MycoKeys 126: 213-238. https://doi.org/10.3897/mycokeys.126.172211

Vassana Supapongsri, Ananya Sahathippayakul, Wanchat Sirisarn, Mohit Chand, Jui-Yu Chou, Piyangkun Lueangjaroenkit   +5 more
openalex   +1 more source

Abstract No. 213 Cephalic Arch Stenosis in Vascular Access: Single-Center Experience of 90 Procedures [PDF]

Meletios Α. Dimopoulos, G. Nistikoulis, N. Giannikas, Michail Theofanis, Christos D. Papageorgiou, V. Taki, Evangelia Christodoulou, Konstantinos Katsanos, Dimitrios Karnabatidis, Panagiotis Kitrou   +9 more
openalex   +1 more source