USP5 Stabilizes TGFBR1 to Drive Vascular Smooth Muscle Cell Senescence and Atherosclerosis
Advanced Science, EarlyView.This study reveals that USP5 drives vascular smooth muscle cell senescence and atherosclerosis by stabilizing TGFBR1, suppressing IDH2, and promoting glycolytic reprogramming, identifying the USP5‐TGFBR1‐IDH2 axis as a potential therapeutic target. ABSTRACT Vascular smooth muscle cell (VSMC) senescence contributes importantly to atherosclerotic plaque ...
Xinhai Cui +5 more
wiley +1 more source
Correction: Satapathy et al. Solid Lipid Nanoparticles (SLNs): An Advanced Drug Delivery System Targeting Brain Through BBB. <i>Pharmaceutics</i> 2021, <i>13</i>, 1183. [PDF]
PharmaceuticsSatapathy MK +6 more
europepmc +1 more source
Advanced Science, EarlyView.An α‐helical peptide, TAB12, designed to mimic the TRIM28 binding interface, competitively disrupts the TRIM28‐BRD7 interaction, thereby blocking ubiquitin‐mediated degradation of the tumor suppressor BRD7. This stabilization unleashes potent anti‐tumor effects across multiple tumor types with a favorable safety profile, offering a feasible strategy ...
Qingqing Wei +10 more
wiley +1 more source
Hormonal, clinical, and survival outcomes in horses and ponies diagnosed with pituitary pars intermedia dysfunction in primary care practice. [PDF]
J Vet Intern MedStapley E +7 more
europepmc +1 more source
Battery‐Inspired Electrochemical Synapses for Neuromorphic Applications
Advanced Science, EarlyView.Battery‐ion‐inspired synaptic devices integrate diverse electrolyte systems (solid, ion‐gel, liquid) with transition metal oxides, two‐dimensional materials, and organic channels to regulate ion‐electron coupling. By tailoring ion transport and host interactions, these platforms enable controllable plasticity and energy‐efficient implementations for ...
Won Woo Lee +6 more
wiley +1 more source
Associations of dietary factors and early-life agricultural occupational background with body composition among older adults with type 2 diabetes in suburban Chengdu: A cross-sectional study. [PDF]
Medicine (Baltimore)Song J +6 more
europepmc +1 more source
Advanced Science, EarlyView.This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan +6 more
wiley +1 more source
Band 7, 213 (Sammlung Friedlaender)
BAND 7, 213 (SAMMLUNG FRIEDLAENDER) Band 7, 213 (Sammlung Friedlaender) (Public Domain ...
core
Sex-Specific Differences in Dyspeptic Symptoms in Children Are Attenuated by <i>Helicobacter pylori</i> Seropositivity. [PDF]
Pediatr Gastroenterol Hepatol NutrIlic D, Jovanovic N, Bjelakovic B.
europepmc +1 more source
Neuromorphic Devices and Computing for Sensing, Memory, and Control
Advanced Science, EarlyView.This review introduces neuromorphic devices made from diverse materials. These devices mimic neuronal functions and architectures and, when integrated with artificial or biological computing, can form closed loops with neurons for pressure, optical, acoustic, and biochemical sensing and modulation.
Zhengguang Zhu +2 more
wiley +1 more source