Results 191 to 200 of about 615,995 (253)

CRISPR and Gene Augmentation Rescue Trabecular Meshwork Dysfunction in iPSC Models of Lowe Syndrome

Advanced Science, EarlyView.
By modeling Lowe syndrome using patient‐derived iPSCs, this study establishes a human disease model that faithfully recapitulates OCRL deficiency‐associated ciliary and cytoskeletal defects. The model enables evaluation of both mutation‐agnostic DNA augmentation and CRISPR‐mediated mutation correction strategies, both of which restore OCRL function and
Siyu Chen, Zhiquan Liu, Wenmin Wang, Qing Wang, Tia J. Kowal, Fan Zhang, Grzegorz Walkiewicz, Faruk Hossen, Herbert M. Lachman, Jinqiong Zhou, Yiting Wang, Yang Sun   +11 more
wiley   +1 more source

Beyond heart failure: giant ascending aortic aneurysm with inflammatory cardiomyopathy-a report of a rare case. [PDF]

Eur Heart J Case Rep
Dębska-Kozłowska A, Supeł K, Wojnicz R, Zielińska M.   +3 more
europepmc   +1 more source

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

Reply to letter 'Chloride as a potential contributor to decongestion therapy. Letter regarding the article "Sodium chloride versus glucose solute as a volume replacement therapy for more effective decongestion in acute heart failure (SOLVRED-AHF): a prospective, randomized, mechanistic study"'. [PDF]

ESC Heart Fail
Biegus J, Ponikowski P.
europepmc   +1 more source

Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy

Advanced Science, EarlyView.
A timeline of the research history of 3D biomimetic scaffold materials and platforms. With advances in biomimetic materials and 3D scaffold technologies, their functional scope has expanded from mimicking basic physical and biochemical properties to increasingly replicating complex pathophysiological processes.
Haitao Zhao, Yuechen Han, Jie Li, Peng Luo, Lin Qi, Zhiwei Xia, Xiaosong Li, Quan Cheng, Chenshen Huang, Wantao Wu, Hao Zhang   +10 more
wiley   +1 more source

Correction: An interactive information based DCNN-BiLSTM model with dual attention mechanism for facial expression recognition. [PDF]

Sci Rep
Jayaraman S, Mahendran A.
europepmc   +1 more source

Beyond Probiotics: Postbiotics for Healthy Aquaculture

Advanced Science, EarlyView.
This critical review assesses limitations of probiotics and proposes postbiotics, preparations of inanimate microorganisms and their metabolites, as a more stable, controlled, and biosafe formulation. Postbiotics offer significant advantages during industrial aquafeed production and storage. However, their practical implementation is currently hindered
Michael Leonidas Chikindas, Delin Xu, Igor V. Popov, Kayque Ordonho Carneiro, Nilufar Arashovna Elova, Gullola Amirovna Bekmurodova, Dildora Amindjanovna Amirsaidova, Astghik Pepoyan, Shakhlo Mirjamalovna Miralimova, Oleg V. Mitrokhin, Liubov S. Sichel, John Tagg, Svetoslav Dimitrov Todorov   +12 more
wiley   +1 more source

Engineering Carbon Cloth‐Catalyst Interfaces for Pt‐Free Hydrogen Evolution Across the Full pH Spectrum

Advanced Science, EarlyView.
Interfacial synergy between carbon cloth and Pt‐free metal/nonmetal catalysts enhances charge transfer, wettability, active site accessibility, and hydrogen bubble release, enabling efficient and durable hydrogen evolution across acidic, neutral, and alkaline media for scalable green hydrogen production.
Syed Mohammed Hubaish, Belal Salah, Khouloud Jlassi, Ali A. Abdelhafiz, Kamel Eid   +4 more
wiley   +1 more source

Grain‐Boundary‐Enriched Cocatalyst Coupled With CuSCN Hole Transport Layer for Efficient Solar Water Oxidation in BiVO4 Photoanode

Advanced Science, EarlyView.
A grain‐boundary‐enriched NiFe cocatalyst is coupled with a CuSCN hole transport layer on BiVO4 photoanodes. The integrated architecture promotes hole extraction, interfacial charge transfer, and surface OER kinetics, highlighting cocatalyst microstructure regulation as a complementary strategy to hole transport layer engineering. ABSTRACT Solar‐driven
Wei Zhao, Yaorong He, Xiao Wang, Lin Zhu, Tong Su, Yujie Zhou, Xiang Li, Peiyao Du, Xiaoquan Lu   +8 more
wiley   +1 more source

Macchina simulatrice il calpestamento dei tappeti erbosi da parte di cavalli in corsa

, 2001
212 213, PERUZZI, ANDREA, Raffaelli M, Miele S, VOLTERRANI, MARCO   +4 more
core