Results 91 to 100 of about 78,590,249 (271)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Trieste, Lanterna, Knackstedt & Co., Hamburg 22

TRIESTE, LANTERNA, KNACKSTEDT & CO., HAMBURG 22 Trieste, Lanterna, Knackstedt & Co., Hamburg 22 ( -
Knackstedt & Co., Hamburg 22
core   +1 more source

IMPROVING THE EFFICIENCY OF IN-SITU URANIUM LEACHING VIA OXYGEN-ENRICHED LIXIVIANT INJECTION

Rudarsko-geološko-naftni Zbornik
This paper explores the optimization of in-situ uranium leaching efficiency through the application of oxygen as an oxidizing agent in the lixiviant. With this objective in mind, geological characteristics of the target site were examined, followed by a ...
Khalidilla Yussupov, Erbolat Aben, Gulfarizada Abdissattar, Saifilmalik Myrzakhmetov, Dalelkhan Akhmetkanov   +4 more
doaj   +1 more source

Vol. 22, nº 22

, 2017
Yes
openaire   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

22@BCN S.A.

, 2002
Exposició i inauguració de l'edifici 22@. - Plans: (DP) Joan Clos (Alcalde de Barcelona) presentant l'acte i altres polítics, (DP) Parts de l'exposició, (DP) Maquetes, (DP) Carrers del districte de Sant MartíDigitalitzat pel ...
22@bcn, S.A., Districte 10. Sant Martí
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Oral history interview with Participant 22

, 2018
Participant 22 discusses their experiences with volunteer work and food pantries after retiring early from teaching due to a disability. They talk about initially volunteering at local food pantries before a change in circumstances caused them to start ...
Participant 22
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