Results 21 to 30 of about 537,087 (229)
Materials & DesignGlass is a representative of fragile material. But it can be used as a good protective cover when strengthened. As a method of such strengthening, so-called “physical tempering” is widely used for large glass plates.
Madoka Ono +5 more
doaj +1 more source
Turkish Journal of Agriculture: Food Science and Technology, 2020 Honey is a popular product consumed for its health benefits. It is an effective antimicrobial an antioxidant agent. Globally, palynological and chemical methods are among the means of authenticating honey quality, geographical origin and floral origin ...
Ernest Uzodimma Durugbo +3 more
doaj +1 more source
The Classification of Blazar Candidates of Uncertain Types
Universe, 2022 In this work, the support vector machine (SVM) method is adopted to separate BL Lacertae objects (BL Lacs) and flat spectrum radio quasars (FSRQs) in the plots of the photon spectrum index against the photon flux, αph∼logF, those of the photon spectrum ...
Jun-Hui Fan +8 more
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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
SensorsIn this work, YF3:Nd3+ powder was synthesized using the microwave-assisted hydrothermal method at a low temperature (140 °C) and short synthesis time (1 h).
Ruan P. R. Moura +7 more
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Molecular Therapy: Nucleic Acids, 2017 Tumor cells express a number of immunosuppressive molecules that can suppress anti-tumor immune responses. Efficient delivery of small interfering RNAs to treat a wide range of diseases including cancers remains a challenge.
Amy H. Lin +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source