Results 191 to 200 of about 394,747 (338)

Exploring AAV‐Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential

Advanced Science, EarlyView.
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu, Wuhui He, Yun Xiao, Qiong Wu, Qing Zhang, Tiesong Zhang, Lei Xu, Xinyi Pang   +7 more
wiley   +1 more source

Characterization of Gene Expression Suppression by Bovine Coronavirus Non-Structural Protein 1. [PDF]

Viruses
Ohkami T, Kitashin I, Kawashima R, Yoshida A, Saito T, Takashima Y, Kamitani W, Nakagawa K.   +7 more
europepmc   +1 more source

PSMD14 Stabilizes SLC7A11 to Ameliorate Glucocorticoid‐Induced Osteoporosis by Suppressing Osteocyte Ferroptosis

Advanced Science, EarlyView.
Glucocorticoid‐induced osteoporosis (GIOP) triggers osteocyte ferroptosis via SLC7A11 degradation. PSMD14 stabilizes SLC7A11 by counteracting glucocorticoid‐driven ubiquitination, preserving cystine uptake and glutathione synthesis. AAV‐mediated PSMD14 delivery or its agonist Pantethine rescues osteocyte survival and bone loss in GIOP mice.
Yifeng Shi, Qian Tang, Sunren Sheng, Hongyi Jiang, Chen Jin, Chencheng Zhou, Chenglong Xie, Lin Zheng, Di Zhang, Hui Xu, Cong Xu, Haiwei Ma, Guangheng Xiang, Wenfei Ni, Xiaoyun Pan, Lei Yang, Huazi Xu, Yu Qian, Aimin Wu, Xiangyang Wang, Gang Zheng   +20 more
wiley   +1 more source

Étude d'une unité de grands-parentaux dans un élevage de lapins hybrides, premiers résultats

Genetics Selection Evolution, 1980
Colin M, Roullere H, Simonnet J, Lucas Y
doaj  

PI-RADSv2.1 combined with PSA density for optimizing prostate biopsy decisions: a retrospective analysis. [PDF]

Front Oncol
Li Y, Wang S, Wang J, Qi X, Liu T, He X, Zhang Y, Zhu Y, Zeng Y.   +8 more
europepmc   +1 more source

A NEW PROCESS FOR THE REMOTE PREPARATION AND FABRICATION OF FUEL ELEMENTS CONTAINING URANIUM-233 OXIDE-THORIUM OXIDE

, 1963
O.C. Dean, R.E. Brooksbank, A.L. Lotts
openalex   +2 more sources

Piezoelectric Biomaterials for Bone Regeneration: Roadmap from Dipole to Osteogenesis

Advanced Science, EarlyView.
Piezoelectric biomaterials convert mechanical forces into electrical signals, offering novel strategies to restore and modulate bone microenvironments for tissue engineering. This review examines molecular dipole origins, spatial arrangements, and pseudo‐piezoelectric mechanisms and highlights dipole‐engineering techniques for osteogenesis regulation ...
Xiyao Ni, Yufei Cui, Mojtaba Salehi, Mui Ling Sharon Nai, Kun Zhou, Cian Vyas, Boyang Huang, Paulo Bartolo   +7 more
wiley   +1 more source

Is a History of Gestational Diabetes Associated With Long-Term Mental Health?-Findings From the GEMS 5-Year Follow Up Study. [PDF]

Brain Behav
Ohene-Agyei P, Gamble GD, Samuel D, Oladimeji O, Liu Q, Harding JE, Crowther CA.   +6 more
europepmc   +1 more source

SEPARATION AND PURIFICATION OF A GRAM OF PROTACTINIUM-233

, 1964
J.W. Codding, J.R. Berreth, R.P. Schuman, W.H. Burgus, R.A. Deal   +4 more
openalex   +2 more sources

Inhalt vom Band 233 [PDF]

, 1966

openalex   +1 more source