Results 91 to 100 of about 3,004,662 (274)

Dual‐Peptide Nanoplatform: Mesoporous Silica Nanoparticles Functionalized With a Cell‐Penetrating Peptide and Loaded With Rationally Designed Antimicrobial Peptides for Tuberculosis Therapy

Advanced Healthcare Materials, EarlyView.
Machine learning–guided engineering of a plectasin‐derived peptide yields DC05, a potent antimycobacterial candidate. Encapsulation into tuftsin‐functionalized mesoporous silica nanoparticles enhances intracellular delivery, stability, and activity against Mycobacterium tuberculosis while maintaining low cytotoxicity and minimal hemolysis. The combined
Christian S. Carnero Canales, Cesar Augusto Roque‐Borda, Ana Carolina Cerqueira Negri, Oswaldo Ramirez Delgado, Letícia Oliveira Catarin Nunes, Flávia Aparecida Resende, Hernane Barud, Norival Alves Santos‐Filho, Saulo Santesso Garrido, Karen Cristina Oliveira, Alexandra Ivo de Medeiros, Rafael Miguel Sábio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

Cosmological Sphaleron from Real Tunneling and Its Fate [PDF]

, 1994
We show that the cosmological sphaleron of Einstein-Yang-Mills system can be produced from real tunneling geometries. The sphaleron will tend to roll down to the vacuum or pure gauge field configuration, when the universe evolves in the Lorentzian ...
A. Hosoya, A. Vilenkin, D. Sudarsky, D. V. Gal'tsov, D. V. Gal'tsov, F. R. Klinkhamer, G. W. Gibbons, G. W. Gibbons, G. W. Gibbons, I. Moss, J. A. Isenberg, J. J. Halliwell, N. S. Manton, N. Straumann, N. Straumann, O. Brodbeck, P. Bizon, R. Bartnik, S. Coleman, S. K. Blau, Shuxue Ding, Y. Hosotani, Y. Verbin   +22 more
core   +2 more sources

Advanced 3D Platforms for Modeling CNS Neuroinflammation: Cell Integration, Techniques, and Challenges

Advanced Healthcare Materials, EarlyView.
This review summarizes the roles of key central nervous system cell types, the extracellular matrix, and the blood‐brain barrier in neuroinflammation, and their integration into diverse 3D culture systems. It examines major incorporation strategies, including direct co‐culture, hydrogel encapsulation, transwell migration assays, and bioprinting ...
Emmanuelle D. Aiyegbusi, Julia Di Stefano, Dearbhaile Dooley   +2 more
wiley   +1 more source

Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models

Advanced Healthcare Materials, EarlyView.
This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre, Margherita Bernardeschi, Matteo Battaglini, Gianni Ciofani   +3 more
wiley   +1 more source

Gut microbiota and functional outcome after ischemic stroke: a Mendelian randomization study

Frontiers in Immunology
BackgroundPrevious studies have shown that gut microbiota dysbiosis could affect clinical prognosis through an unknown mechanism. However, the causal relationship between the gut microbiota and the functional outcome after ischemic stroke remains unclear.
Dian Qu, Deming Jiang, Yan Xin, Guichun Yang, Huan Liang, Linlin Wang   +5 more
doaj   +1 more source

Solvability of the Dirichlet Problem for Elliptic Equations in Weighted Sobolev Spaces on Unbounded Domains

Boundary Value Problems, 2008
This paper is concerned with the study of the Dirichlet problem for a class of second-order linear elliptic equations in weighted Sobolev spaces on unbounded domains of ℝn, n≥3.
Maria Transirico, Sara Monsurrò, Serena Boccia   +2 more
doaj   +1 more source

Chemical Analysis of Surfaces Using Alpha Particles [PDF]

Chemical analysis of surfaces using alpha particle interactions in instruments incorporating curium 242 alpha sources and semiconductor silicon ...
Franzgrote, E., Patterson, J. H., Turkevich, A. L.   +2 more
core   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Editorial 24.2

Trabalho & Educação, 2016
"[...] Quero trabalhar em paz [...] quero trabalho honesto em vez de escravidão [...] [e] deve haver algum lugar onde o mais forte não consegue escravizar quem não tem chance...".
Geraldo Márcio dos Santos, Daisy Moreira Cunha, Ailton Vitor Guimarães   +2 more
doaj  

Engineering Resatorvid‐Loaded Sub‐Microgels of Epigallocatechin‐3‐gallate/Hyaluronic Acid to Treat Acute Lung Injury

Advanced Healthcare Materials, EarlyView.
This study presents HAEP@Res sub‐microgels as a lung‐targeted delivery system integrating antioxidant activity with anti‐inflammatory therapy. The sub‐microgels demonstrate excellent biocompatibility, efficiently scavenge intracellular ROS, and downregulate pro‐inflammatory cytokines and genes in a Bleo‐induced ALI mouse model. These findings highlight
Bo Liu, Olawale Alimi Alimi, Benjamin Stearnes, Svetlana Romanova, Brady J. Sillman, Mena Asha Krishnan, Kristina Bailey, Benson J. Edagwa, Huanhuan Joyce Chen, Han‐jun Wang, Bin Duan   +10 more
wiley   +1 more source