Results 201 to 210 of about 107,165 (276)

Stability analysis of reference genes in Maconellicoccus hirsutus across various conditions including dsRNA treatment. [PDF]

Sci Rep
Negi N, Ramasamy GG, Selvamani SB, Reddy KVN, Suman TC, Rao AS, Thiruvengadam V, Mohan M, Dubey VK, Sushil SN.   +9 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Extracellular Small RNAs in Human Milk: Molecular Profiles, Stability and Fragment-Specific Responses in Cell-Based Assays. [PDF]

Noncoding RNA
Claus C, Borini Etichetti C, Costa B, Grosso JB, Tosar JP, Chorostecki U, Spinelli SV.   +6 more
europepmc   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Two New Species of <i>Lactifluus</i> (Basidiomycota, Russulales) Sections <i>Piperati</i> and <i>Albati</i> Inhabiting Tropical <i>Quercus</i> Forests of Eastern Mexico. [PDF]

J Fungi (Basel)
Bandala VM, Susan P, Ramos A, Montoya L.
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Conserved shifts in sperm small non-coding RNA profiles during mouse and human aging. [PDF]

EMBO J
Shi J, Zhang X, Cai C, Liu S, Yu J, James ER, Liu L, Emery BR, McMurray Bires MR, Torres-Arce E, Rawal HC, Ramsay J, Kunisaki J, Zhou C, Milstone DS, Patti ME, Yang X, Jenkins TG, Quinlan A, Cairns BR, Schimmel P, Hotaling JM, Aston KI, Zhou T, Chen Q.   +24 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

A new ergasilid copepod from lates perches in East Africa: morphology, phylogenetics, and genetic structure of <i>Ergasilus ereimia</i> sp. nov. [PDF]

Front Vet Sci
Vandenberg F, Kmentová N, Karanja H, Van Steenberge M, Vranken N, Vanhove MPM, Thys KJM.   +6 more
europepmc   +1 more source